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ImmunoSero Continuation > Antibodies > Flashcards

Antibodies Flashcards

1
Q

Domain of immunoglobulin that is responsible for the specificity of the antibody.

A

Variable Region

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2
Q

It is the specific portion in the variable
region where antigen binding takes place

A

HYPERVARIABLE PORTION/ REGION

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3
Q

Domain of immunoglobulin that binds with the complement proteins specifically the C1q

A

CH2 (Constant Heavy Chain 2)

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4
Q

Domain of immunoglobulin that is responsible for the cytotropic reactions involving macrophage, monocytes, mast cells, Cytotoxic Killer Cells and B cells

A

CH3 (Constant Heavy Chain 3)

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5
Q

Domain of immunoglobulin that is responsible for the light chain type of the antibody

A

CL (Constant Light Chain)

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6
Q

The light chain type can either be a ______ or ______.

A

Kappa; Lambda

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7
Q

What is the percentage of light chain that is classified as Kappa?

A

65%

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8
Q

Kappa is predominantly present in _______

A

Ab

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9
Q

What are the 5 classes of immunoglobulins?

A

(GAMDE) IgG, IgA, IgM, IgD, IgE

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10
Q

What is the percentage of light chain that is classified as Lambda?

A

35%

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11
Q

The predominant Ig in healthy human serum

A

IgG

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12
Q

What are the 4 subclasses of immunoglobulin G?

A

IgG1, IgG2, IgG3, IgG4

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13
Q

What is the antibody that has the longest half-life or circulation life?

A

IgG

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14
Q

What is the antibody that is predominant in the secondary or the anamnestic response?

A

IgG

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15
Q

What is the antibody that provides immunity to the newborn?

A

IgG

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16
Q

What is the only antibody that can actively cross the placenta?

A

IgG

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17
Q

What is the antibody that can provide neonatal immunity? - IgG

A

IgG

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18
Q

What is the antibody that is considered as the best precipitating antibody?

A

IgG

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19
Q

Why can IgG actively cross the placenta?

A

because it is the smallest antibody

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20
Q

The subclasses of IgG that can actively cross placental

A

IgG1 & IgG3

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21
Q

True or False. IgG is a cold-reacting antibodies.

A

False. It is warm- reacting

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22
Q

True or False. IgG participates in agglutination and precipitation

A

True

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23
Q

True or False. IgG optimally reacts at room temperature.

A

False. @37°C

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24
Q

Tell the percentage of the stated IgG sublass in the circulation and its corresponding number of disulfide bonds: IgG1

A

66%; 2

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25
Q

Tell the percentage of the stated IgG sublass in the circulation and its corresponding number of disulfide bonds: IgG2

A

23%; 4

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26
Q

Tell the percentage of the stated IgG sublass in the circulation and its corresponding number of disulfide bonds: IgG3

A

7%; 15

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27
Q

Tell the percentage of the stated IgG sublass in the circulation and its corresponding number of disulfide bonds: IgG4

A

4%; 2

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28
Q

It is a pentameric immunoglobulin

A

IgM

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29
Q

The antibody that is first to appear in phylogeny and the last to leave in senescence

A

IgM

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30
Q

The antibody that is first appear after a primary antigenic stimulus

A

IgM

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31
Q

True or False. IgM is a warm-reacting antibodies that reacts at ref temperature (4°C)

A

False. IgM is cold-reacting antibody that reacts at ref temperature (4°C)

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32
Q

True or False. IgM is a cold-reacting antibodies.

A

True

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33
Q

What are the functions of IgM?

A

Complement fixation, Agglutination reaction, Opsonization, Neutralization of toxin

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34
Q

The antibody that is considered as the best agglutinating antibody

A

IgM

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35
Q

IgM in agglutination reaction can initiate________

A

Lattice Formation

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36
Q

The antibody that is responsible for mucosal immunity

A

IgA

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37
Q

The antibody, aside from IgG, that is transferred by the mother thru colostrum

A

IgA

38
Q

The antibody that the function is still unknown but believes to play a role in immunoregulation

A

IgD

39
Q

IgA exist as monomer in ______ and dimer in ______

A

Blood; Secretion

40
Q

What are the 2 subclasses of immunoglobulin A?

A

IgA1, IgA2

41
Q

It is responsible for maintaining the IgA structure in the secretion by preventing enzymatic degradation of the antibody structure

A

secretory component

42
Q

How does the secretion component of IgA maintain its structure?

A

by preventing enzymatic degradation of the antibody structure

43
Q

The antibody that can be found on the surface of B- lymphocytes

A

IgD

44
Q

The antibody that is postulated to be an anti-idiotypic antibody

A

IgD

45
Q

The antibody that is least abundant in the serum

A

IgE

46
Q

IgE is originally known as ______

A

Reaginic antibody

47
Q

Heat-labile antibody, originally known as Reaginic antibody

A

IgE

48
Q

This antibody binds strongly to mast cell (tissues) and basophil (intravascular circulation) receptor

A

IgE

49
Q

This antibody mediates some types of hypersensitivity reactions

A

IgE

50
Q

Histamine released is due to the binding to the attached allergen of what type of immunoglobulin

A

IgE

51
Q

This type of antibody is released during helminthic infection

A

IgE

52
Q

Molecular weight of IgG in Daltons

A

150T

53
Q

Molecular weight of IgA in Daltons

A

160-400T

54
Q

Molecular weight of IgM in Daltons

A

900T

55
Q

Molecular weight of IgD in Daltons

A

180T

56
Q

Molecular weight of IgE in Daltons

A

190T

57
Q

Half-life of IgG

A

21-23 days

58
Q

Half-life of IgA

A

5-6 days

59
Q

Half-life of IgM

A

5 days

60
Q

Half-life of IgD

A

2-3 days

61
Q

Half-life of IgE

A

2-3 days

62
Q

How many subclasses do IgG have?

A

4

63
Q

How many subclasses do IgA have?

A

2

64
Q

How many subclasses do IgM have?

A

2

65
Q

How many subclasses do IgD have?

A

None

66
Q

How many subclasses do IgD have?

A

None

67
Q

How many domains do IgG have?

A

4

68
Q

How many domains do IgA have?

A

4

69
Q

How many domains do IgM have?

A

5

70
Q

How many domains do IgD have?

A

4

71
Q

How many domains do IgE have?

A

5

72
Q

Does IgG activate complement?

A

Yes (specifically Classical Pathway), except IgG4

73
Q

Does IgA activate complement?

A

Alternative pathway only (Provided that IgA is in aggregate s for it to elicit or induce the activation )

74
Q

Does IgM activate complement?

A

Yes (specifically Class ical Path way) , most efficient

75
Q

Does IgD activate complement?

A

no

76
Q

Does IgE activate complement?

A

No

77
Q

What is the major Ig in 2° Immune response?

A

IgG

78
Q

Immunoglobulins characterized of having J chains

A

IgA & IgM

79
Q

Antibody involved in B cell activation

A

IgD

80
Q

Antibody that is Heat & Acid Labile

A

IgD

81
Q

Antibody that is susceptible to enzyme degradation

A

IgD

82
Q

Antibody that is associated with Immediate hypersensitivity

A

IgE

83
Q

Antibody that binds basophils and mast cells

A

IgE

84
Q

Antibody that is elevated during parasitic infections

A

IgE

85
Q

Other name of IgG

A

Serum Ig

86
Q

Other name of IgA

A

secretory Ig

87
Q

Other name of IgM

A

Pentameric Ig

88
Q

Other name of IgE

A

Reagenic Ig

89
Q

True or False. Pentameric Ig is also known as IgA

A

Pentameric Ig is IgM

90
Q

True or False. Secretory Ig is also known as IgG

A

False. Secretory Ig is IgA

91
Q

True or False. Serum Ig is also known as IgA

A

False. Serum Ig is IgG

92
Q

True or False. Reagenic Ig is also known as IgM

A

False. Reagenic Ig is IgE

ImmunoSero Continuation (2 decks)

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