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Antibiotics > Antibiotics-attenuated > Flashcards

Antibiotics-attenuated Flashcards

1
Q

Amphotericin:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
A
  1. Group: Antifungal
  2. Mechanism: membrane permeability
  3. Target: Fungi
  4. Side effect: Very bad. Anemia, etc
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2
Q

Nystatin:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
A
  1. Group: Anti-fungals
  2. Mechanism: binds to ergosterol, changing membrane permeability
  3. Target: Fungi
  4. Side effect: Also bad
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3
Q

Fluconazole, Itra-, keto-

  1. Group:
  2. Mechanism:
  3. Target:
A
  1. Group: Antifungals
  2. Mechanism: Inhibits ergosterol synthesis
  3. Target: systemic mycoses
  4. Side effect: ?
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4
Q

Caspofungin:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
A
  1. Group: antifungal
  2. Mechanism: inhibits glucan cell wall synthesis
  3. Target: Candida albicans
  4. Side effect: ?
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5
Q

Flucocytosine:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
A
  1. Group: Antimetabolite/antifungal
  2. Mechanism: inhibits thymidylate synthetase
  3. Target: antifungal
  4. Side effect: ?
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6
Q

Caspofungin:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
A
  1. Group: antifungal
  2. Mechanism:
  3. Target:
  4. Side effect:
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7
Q

Antimetabolites:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
A
  1. Group: Antimetabolite/antifungal
  2. Mechanism: inhibits thymidylate synthetase
  3. Target: antifungal
  4. Side effect: ?
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8
Q

Ciprofloxacin

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Fluoroquinolones
  2. Mechanism: Interferes with DNA replication
  3. Target: broad spectrum, pseudomonas, and MRSA
  4. Side effect:
  5. cidal/static: cidal
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9
Q

Moxyfloxacin:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Fluoroquinolone
  2. Mechanism: Inhibits DNA gyrase
  3. Target: Broad spectrum. Later generation of fluoroquinolones
  4. Side effect:
  5. cidal/static: cidal
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10
Q

Metronidazole:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
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11
Q

Nalidixic Acid:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group:Quinolones
  2. Mechanism: Inhibit DNA gyrase
  3. Target: Gm - and enterics
  4. Side effect:
  5. cidal/static: Cidal
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12
Q

Muprocin

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: 50S inhibitor
  2. Mechanism: Inhibits tRNA
  3. Target: Nasal MRSA
  4. Side effect:
  5. cidal/static: Can be either. Concentration dependent
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13
Q

Oxazoledones

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: 50S inhibitors
  2. Mechanism: Inhibits 16S and 23S rRNA
  3. Target: Gram +
  4. Side effect:
  5. cidal/static: Static
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14
Q

Chloramphenicol:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: 50 S subunit inhibitor
  2. Mechanism: Blocks chain elongation
  3. Target: Gram +, gram -, anaerobes. Wide spectrum.
  4. Side effect: gray baby syndrome, aplastic anemia
  5. cidal/static: static
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15
Q

Azithromycin and erythromycin

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Macrolides (50S inhibitor)
  2. Mechanism: Prevents chain elongation
  3. Target: Gram +
  4. Side effect:
  5. cidal/static: static
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16
Q

Azithromycin and erythromycin

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Macrolides (50S inhibitor)
  2. Mechanism: Prevents chain elongation
  3. Target: Gram +
  4. Side effect:
  5. cidal/static: static
17
Q

Streptomycin, gentamicin, amikamycin, kanamycin

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Aminoglycosides (30 S inhibitors)
  2. Mechanism: Binds directly to 30S and prevents proofreading mechanism. Causes production of misfolded proteins
  3. Target: 30 S ribosomal unit itself
  4. Side effect: CN 8 toxicity, renal toxicity
  5. cidal/static: CIDAL.
18
Q

Polymyxin B/E

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Membrane permeability
  2. Mechanism: Positive charge binds to negatively charged membrane
  3. Target: Gram negative, Pseudomonas!
  4. Side effect:
  5. cidal/static: Cidal
19
Q

Polymyxin B/E

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Membrane permeability
  2. Mechanism: Positive charge binds to negatively charged membrane
  3. Target: Pseudomonas!
  4. Side effect:
  5. cidal/static:
20
Q

Daptomycin

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Membrane permeability
  2. Mechanism: Lipopeptide inserts into cytoplasmic membrane
  3. Target: Gram +
  4. Side effect:
  5. cidal/static: cidal
21
Q

Bacitracin:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Cell wall synthesis inhibitors
  2. Mechanism: Inhibits lipid carrier step in cell wall synthesis
  3. Target: Gram +
  4. Side effect: only used topically b/c toxic
  5. cidal/static: cidal
22
Q

Cycloserine

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Cell wall synthesis inhibitor
  2. Mechanism: Inhibits D-ala
  3. Target: TB
  4. Side effect:
  5. cidal/static: Cidal
23
Q

Vancomycin

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Cell wall synthesis inhibitor
  2. Mechanism: Binds D-Ala-D-Ala
  3. Target: GRAM POSITIVES. MRE< MRSA<VRE.
  4. Side effect:
  5. cidal/static: Cidal
24
Q

Aztreonam:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Monobactam, beta-lactamase resistant betalactam
  2. Mechanism:
  3. Target: Gram negatives
  4. Side effect:
  5. cidal/static: cidal
25
Q

Aztreonam:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Monobactam, beta-lactamase resistant betalactam
  2. Mechanism:
  3. Target: Gram negatives
  4. Side effect:
  5. cidal/static: cidal
26
Q

Cephazolin:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: 1st generation cephalosporin
  2. Mechanism:
  3. Target: Gram +
  4. Side effect:
  5. cidal/static: cidal
27
Q

Cefuroxime

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Cephalosporin, 2nd generation. beta lactam
  2. Mechanism:
  3. Target: Gram Positive, Gram negative
  4. Side effect:
  5. cidal/static: cidal
28
Q

Ceftraixone

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group:3rd generation cephalosporin, beta lactam, betalactamase resistant
  2. Mechanism:
  3. Target: GRAM POSITIVE, NEGATIVE, and pseudomonas
  4. Side effect:
  5. cidal/static: Cidal
29
Q

Methicillin, oxacillin, nafcillin:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Betalactam, acid and betalactamase resistant
  2. Mechanism: Inhibits cell wall synthesis.
  3. Target: Gram +, extended spectrum, staph
  4. Side effect:
  5. cidal/static: cidal
30
Q

Ampicillin, amoxicillin:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Aminopenicillin
  2. Mechanism: Cell wall synthesis inhibition, resists hydrolysis
  3. Target: Gram positive, braod spectrum
  4. Side effect:
  5. cidal/static: Cidal
31
Q

Ampicillin, amoxicillin:

  1. Group:
  2. Mechanism:
  3. Target:
  4. Side effect:
  5. cidal/static:
A
  1. Group: Aminopenicillin
  2. Mechanism: Cell wall synthesis inhibition, resists hydrolysis
  3. Target: Gram positive, braod spectrum
  4. Side effect:
  5. cidal/static: Cidal

Antibiotics (2 decks)

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