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Surgery > Antibiotics > Flashcards

Antibiotics Flashcards

1
Q

Penicillins MOA

A

Inhibition of cell wall synthesis

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2
Q

Penicillins cidal vs. static

A

cidal

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3
Q

Penicillins time vs. conc

A

Time dependent

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4
Q

Penicillins Spectrum

A

Naturals: G+, Staph, Anaerobic
Potentiated: G+, staph, G-, anaerobic, some also pseudamonas

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5
Q

Penicillins examples

A

Penicillin, diclocacillin, ampicillin, amoxicillin, amoxi/clav, ticarcillin, ticarcillin/clav

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6
Q

Carbapenems MOA

A

Inhibition of cell wall synthesis

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7
Q

Carbapenems cidal vs. static

A

cidal

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8
Q

Carbapenems time vs. conc

A

time

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9
Q

Carbapenems spectrum

A

Broad. G+, staph, G-, pseudamonas, anaerobic

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10
Q

Carbapenems examples

A

Meropenem, Imipenem

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11
Q

Cephalosporins 1st gen MOA

A

Inhibition of cell wall synthesis

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12
Q

Cephalosporins 1st gen cidal vs. static

A

cidal

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13
Q

Cephalosporins 1st gen time vs. conc

A

time

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14
Q

Cephalosporins 1st gen spectrum

A

G+&raquo_space; G-, staph, some anaerobes

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15
Q

Cephalosporins 1st gen examples

A

Cephalexin, Cefazolin

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16
Q

Cephalosporins 2nd gen MOA

A

Inhibition of cell wall synthesis

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17
Q

Cephalosporins 2nd gen cidal vs. static

A

cidal

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18
Q

Cephalosporins 2nd gen time vs. conc

A

time

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19
Q

Cephalosporins 2nd gen Spectrum

A

G+>G-, staph, good anaerobe, cefoxitin good for anaerobes

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20
Q

Cephalosporins 2nd gen examples

A

cefoxitin

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21
Q

Cephalosporins 3rd gen MOA

A

Inhibition of cell wall synthesis

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22
Q

Cephalosporins 3rd gen cical vs. static

A

cidal

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23
Q

Cephalosporins 3rd gen time vs. conc

A

time

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24
Q

Cephalosporins 3rd gen Sectrum

A

G+ < G-, staph not as good, good anaerobe

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25
Q

Cephalosporins 3rd gen examples

A

Cefpodoxime, Cefovecin, etc

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26
Q

Fluoroquinolones MOA

A

Nucleic acid synthesis inhibitor - inhibits DNA gyrase and topoisomerase

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27
Q

Fluoroquinolones cidal vs. static

A

cidal

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28
Q

Fluoroquinolones time vs. conc

A

conc

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29
Q

Fluoroquinolones spectrum

A

Excellent G-, Good G+, Staph, weak anaerobes

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30
Q

Fluoroquinolones examples

A

Enrofloxacin, marbofloxacin, prado, orbi, etc

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31
Q

Glycopeptides MOA

A

Inhibits cell wall synthesis

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32
Q

Glycopeptides cidal vs. static

33
Q

Glycopeptides time vs. conc

34
Q

Glycopeptides spectrum

A

G+ only, staph, anaerobes

35
Q

Glycopeptides examples

A

Vancomycin

36
Q

Lincosamides MOA

A

Inhibits protein synthesis - binds 50s ribosome

37
Q

Lincosamides cidal vs. static

A

static (Cidal at high pH)

38
Q

Lincosamides time vs. conc

39
Q

Lincosamides spectrum

A

Excellent G+ and anaerobes, staph, minimal G-

40
Q

Lincosamides examples

A

Clindamycin, lincosamycin

41
Q

Chloramphenicol MOA

A

Inhibits protein synthesis - binds 50s ribosome

42
Q

Chloramphenicol cidal vs. static

43
Q

Chloramphenicol time vs. conc

44
Q

Chloramphenicol spectrum

A

Good G+, moderate G-, excellent anaerobes

45
Q

Chloramphenicol examples

A

…Chloramphenicol

46
Q

Macrolides MOA

A

Inhibits protein synthesis - binds 50s ribosome

47
Q

Macrolides cidal vs. static

48
Q

Macrolides time vs. conc

49
Q

Macrolides spectrum

A

Excellent G+, staph, good anaerobes, Some G- (azithro more than erythro)

50
Q

Macrolides examples

A

erythromycin, azithromycin

51
Q

Metronidazole MOA

A

Inhibits nucleic acid synthesis

52
Q

Metronidazole cidal vs. static

53
Q

Metronidazole time vs. conc

54
Q

Metronidazole spectrum

A

Excellent anaerobes

55
Q

Metronidazole examples

56
Q

Tetracyclines MOA

A

Inhibits protein synthesis - binds 30s ribosome

57
Q

Tetracyclines cidal vs. static

58
Q

Tetracyclines time vs. conc

59
Q

Tetracyclines spectrum

A

G+, staph, G-, anaerobes

60
Q

Tetracyclines examples

A

Doxycycline, minocycline

61
Q

Tetracyclines special facts

A

esphageal stricture

62
Q

Aminoglycosides MOA

A

Inhibits protein synthesis - binds 30s ribosome (maybe 50s too per Boothe?)

63
Q

Aminoglycosides cidal vs. static

64
Q

Aminoglycosides time vs. conc

65
Q

Aminoglycosides spectrum

A

G-, staph, pseudomonas

66
Q

Aminoglycosides examples

A

Gentamicin, amikacin, neomycin

67
Q

Aminoglycosides special facts

A

Nephrotoxic, ototoxicity

68
Q

Sulfa drugs MOA

A

Blocs folic acid synthesis
Sulfadiazine - inhibits folic acid synthetase
Trimethoprim 0 inhibits folic acid reductase

69
Q

Sulfa drugs cidal vs. static

A

Sulfa alone - static

TMS - cidal

70
Q

Sulfa drugs time vs. conc

71
Q

Sulfa drugs Spectrum

A

G+, G-, staph, anaerobic

72
Q

Sulfa drugs examples

73
Q

Sulfa drugs special facts

A

Can cause KCS
Dobermans hypersensitive
Can cause immune diseases

74
Q

Rifampin MOA

A

Inhibits RNA synthesis

75
Q

Rifampin cidal vs. static

76
Q

Rifampin time vs. conc

77
Q

Rifampin spectrum

A

G+, staph, anaerobes

78
Q

Rifampin examples

A

rifampin. yup.

79
Q

Rifampin special facts

A

Orange urine, rapid development of resistance

Surgery (7 decks)

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