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Pharmacology > Antibiotics > Flashcards

Antibiotics Flashcards

1
Q

Penicillins w/ Beta lactamase inhibitors

drug examples

A

Ampicillin/sulbactam,

piperacillin/tazobactam

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2
Q

Quinolones

drug examples

A

Levofloxacin

Ciprofloxacin

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3
Q

Cefazolin

A

1st gen Cephalosporin, Ancef
MOA similar to PCNs, but usually stable against bac beta lactamases
gram+ and some gram-

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4
Q

Cefuroxime

A

3nd gen Cephalosporin
MOA similar to PCNs, but usually stable against bac beta lactamases
gram+ and more gram-

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5
Q

Cefoxitin

A

2nd gen Cephalosporin
MOA similar to PCNs, but usually stable against bac beta lactamases
gram+ and more gram-

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6
Q

Aminoglycosides

Drug examples

A

Gentamycin

Tobramycin

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7
Q

Clindamycin

A

Tetracycline
broad spectrum: gram+, gram-, anaerobes
good penetration at abscesses
risk factor for C. diff

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8
Q

Aminoglycosides

Drug examples and uses

A

Gentamycin
Tobramycin
Aerobic gram- enteric bacteria

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9
Q

Erythromycin

A

Macrolide

PCN sub for allergic pts

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10
Q

Aminoglycosides

MOA

A

Bactericidal
inhibit protein syntheses at the 30S rib subunit
transport is O2 dependent and enhanced w/ beta lactam drugs

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11
Q

Trimethoprim / Sulfamethaxazole combo

TMP-SMX combo

A

Sulfonamides
inhibit bacterial folate synthesis, no PABA
concentrates in prostatic fluid

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12
Q

Metronidazole

A

Anaerobic bacteria= GI and abscesses

Kills C. diff

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13
Q

Azithromycin

A

Macrolide
Good tissue penetration
Slow release from tissues
Z-pack

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14
Q

Neomycin-gramicidin-polymixin B

A

used in eyes for ophthalmic cases?

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15
Q

Quinolones

MOA

A

Inhibit bacterial topoisomerase II (DNA gyrase)

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16
Q

Quinolones

Uses

A

Excellent gram- and moderate gram+

good empiric therapy for UTIs

17
Q

Quinolones

Adverse effects

A

QT prolongation
Avoid in pregnant and peds( fucks closed growth plates)
Tendonitis

18
Q

Quinolones

Adverse effects

A

QT prolongation
Avoid in pregnant and peds (fucks closed growth plates)
Tendonitis

19
Q

Surgical Prophylaxis

A

Need serum and tissue of drug > MIC for bug
start infusion 60min before cut
120min for quinolone and vancomycin
need redose for long cases

20
Q

Surgical Procedures that need Anaerobic drugs

A

Colorectal, Gynecologic, OB, head/neck cases

21
Q

Cefotetan

A

2nd gen Cephalosporin
MOA similar to PCNs, but usually stable against bac beta lactamases
gram+ and more gram- AND Anaerobes

Pharmacology (5 decks)

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