Adrenergic Drugs Flashcards
phenylephrine receptor affinity
alpha 1 agonist
phenylephrine CV effects
A1:Potent increase in peripheral resistance leads to increase in DPB
HR decrease due to indirect effect of baroreceptors
No change in PP or contractility
NE receptor affinity
alpha 1»beta 1 agonist
NE CV effects
A1:Potent increase in peripheral resistance leads to increase in DBP
Contractility increase leads to increase in PP
HR changes relative to alpha 1 and beta 1 effects
Epi receptor affinity
beta 1=beta 2» alpha 1 agonist
Epi CV effects
Dose related effects-lower dose=more mixed effects
-higher dose=more alpha 1 effects
Venous tone, peripheral resistance, and HR all can increase or decrease relative to dose
Isoproterenol receptor affinity
beta 1=beta 2 agonist
ISO CV effects
B2:decrease in peripheral resistance leads to decrease in DBP
B1: increase in contractility and HR leads to increase in PP
Mean BP drops
Epi clinical uses
Inotrope (heart failure) Vasopressor Bronchodialator Anaphylaxis Bradycardia
NE clinical uses
Vasopressor
Isoproterenol clinal uses
Bronchodilator
Dobutamine receptor affinity
beta 1»beta 2
Dobutamine clinical uses
Inotrope
Phenylephrine clinical uses
Vasopressor
decongestant
Mydriatic (pupil dilator)
Clonidine and Dexmedetomidine
receptor affinities
alpha 2 agonist
presynaptic»_space;> postsynaptic receptor
