Antibiotics

Question 1

Which classes of antibiotics work by inhibiting cell wall (petidoglycan/ murein) synthesis and assembly? (5)

Answer 1

Beta-lactams (penicillin)
Monobactams (aztreonam)
Carboxypenems (imepenem)
Glycopeptides (vancomycin)
Some polypeptides (bactriacin)

Question 2

Which classes of abx work by inhibiting translation (protein synthesis)? (6)

Answer 2

Aminoglycosides (streptomycin, gentamicin)
Lincomycins (clindamycin)
Macrolides (erythromycin, azithromycin)
Rifamycins (rifampacin)
Tetracyclines (doxy)
Chloramphenicol

Question 3

Which classes of antimicrobials work by damaging cytoplasmic membranes? (2)

Answer 3

Some polypeptides (polymixin)
Polyenes (amphoteracin, nystatin)- inactivate membranes containing sterols

Question 4

Which classes of abx inhibit DNA replication? (2)

Answer 4

Quinolones (nalidixic acid)

Fluoroquinolones (ciprofloxacin)

Question 5

Which abx work by affecting folate? (2)

Answer 5

Trimethoprim & PAC- both growth factor analogs

Question 6

Which abx inhibits mycolic synthesis? (1)

Answer 6

Isoniazid (TB)