Antibiotics 4 - Tetracyclins, Folate inhibitors, and weird ones

Question 1

Tetracycline, doxycycline, minocycline

Answer 1

Tetracyclines (bind to 30S ribosome).

Question 2

When are tetracyclines used?

Answer 2

For atypical organisms like intracellular bacteria:

Rickettsiae, Mycoplasma, Chlamydia, Borrelia.

Question 3

How should tetracyclines be taken?

Answer 3

Orally, and do not take with antacids or Calcium,

b/c inhibits absorbtion

Question 4

Main concerns with Tetracyclins?

Answer 4

stains teeth, inhibits bone growth in children,

and causes photosensitivity.

Question 5

Fluoroquinolones?

Answer 5

inhibit DNA Gyrase.

Question 6

_____-floxacin?
Ciprofloxacin, Levofloxacin,
Moxifloxacin, Gemifloxacin?

Answer 6

Fluoroquinolones (inhibit DNA Gyrase).

Question 7

Main concern with ____-floxacin fluoroquinolones?

Answer 7

(“fluoroquinolones can cause you to fall to the flour!”),
toxicity to Cartilage with
increased risk of tendonitis and tendon rupture.

Question 8

Sulfamethoxazole-Trimethoprim?

Answer 8

Sulfonamide drugs that together BLOCK FOLATE which inhibits DNA and protein synthesis.

Question 9

Main concern with Sulfa drugs?

Answer 9

Severe lethal Skin reactions (SJ/TEN),
hemolytic anemia if G6PD deficient,
kernicterus in Newborns (displaces bilirubin).

Question 10

Metronidazole?

Answer 10

Kills Protazoa and Anaerobic infections.

Question 11

Main concern with Metronidazole?

Answer 11

disulfiram-like sickness reaction to alcohol.

Question 12

Nitrofurantoin

Answer 12

for UTIs,

only activated in urinary tract

Question 13

Isoniazid

Answer 13

for Tuberculosis (mycobacterium).