Antibiotics

Question 0

Vancomycin

Answer 0

Glycopeptide

Inhibit cell wall synthesis by capping

Question 1

Penicillin
Amoxicillin
Flucloxacillin
Cephalexin

Answer 1

Class - Penicillin beta lactams.
MOA - Inhibit transpeptidase irreversible. Cell wall synthesis inhibitors. Resistance - Resistance by mutation, beta lactamases.
Uses - broud spec. UTIs, RTIs.

Question 2

Gentamycin

Answer 2

Aminoglycocides

Inhibit protein synthesis at 30S

Question 3

Erythromycin

Answer 3

Macrolide

Inhibits protein synthesis at 50S

Question 4

Tetracycline

Answer 4

Class - Tetracyclines
MOA - Protein synthesis inhibitor at 30S unit
Resistance - effluent protein, protein dislodgement from ribosome
Uses - UTIs and STIs

Question 5

Ciprofloxacin

Answer 5

Fluroquinolones

Inhibit dna gyrase to inhibit dna replication

Question 6

Folate inhibitors

Answer 6

Methotrexate inhibits dihydrofolate reductase
Resistance - reduced uptake proteins, altered DHFR, increased DHFR
Uses - cancer, arthritis

Question 7

Rifampicin

Answer 7

MOA - inhibition of DNA dependant RNA polymerase
Resistance - RNA polymerase mutation
Uses - mycobacteria