antibiotics 3

Question 1

Drugs of choice for uncomplicated Skin and soft tissue infections

Answer 1

First line:

• Penicillins (Ampicillin) ==> more broad
• 1st Gen Ceph (cephalexin) ==> narrow spectrum

If Allergies = Vancomycin or clindamycin

Question 2

Drugs of choice for Complicated tissue infections

Answer 2

complicated infections = burns, diabetes mellitus, pressure ulcers, trauma/surgical wound infection.

First line = Penicillin + lactamase inhibitor

• Ticarcillin (broad)

Question 3

Drugs of choice for suspected MRSA skin and soft tissue infection

Answer 3

VANCOMYCIN, LINEZOLID, DAPTOMYCIN

Question 4

Drug of choice for treatment of Osteomyelitis

Answer 4

Empiric:

–> Vancomycin

–> Cephalosporins (Ceftriaxone or cefepime) = 3rd or 4th gen

(CELL WALL INHIBITORS)

Question 5

Drugs of choice for surgeries of bone and joint infections

Answer 5

• Penicillin (ticarcillin) + Lactamase inhibitor

(Broad coverage)

Question 6

Drug of choice for Septic arthritis (empiric and mrsa)

Answer 6

Empriric

–> Ceftriaxone

MRCA

–> Vancomycin, linezolid, daptomycin

Question 7

drugs of choice for upper respiratory tract infections

Answer 7

ACUTE SINUSITIS = Amoxicillin + Clauvulanate (penicillin + lactamase inhibitor)

CHRONIC BRONCHITIS = SAME AS ACUTE SINUSITIS

PHARYNGITIS (narrow spectrum because more likly to be gram (+)

–> FIRST LINE = Penicillin or amoxicillin

–> allergy = 1st gen Cephalosporin

Question 8

Describe drug choice for Community acquired bacterial pneumonia

Answer 8

Ambulatory (no B-lactams because of mycoplasma)

–> Macrolide = Erythromycin, azithromycin, clarithromycin

hospitalization

–> Beta-Lactam + Macrolide (3rd gen cephlosporin)

MRSA

–> VANCOMYCIN or Linezolid

Question 9

drug of choice for hospital acquired, healthcare-associated, ventilator-associated PNEUMONIA

Answer 9

EMPIRIC = Ceftriaxone (levofloxacin or moxifloxacin)

MRSA = Vancomycin or linezolid

Question 10

TREATEMTN OF URINARY TRACT INFECTIONS/PROSTATITIS

Answer 10

Uncomplicated:

• CYSTITIS = Trimethoprim/sulfamethoxazole (TMP-SMX)
• PYELONEPHRITIS = TMP-SMX or Fluoroquinolone

COMPLICATED

–> Fluoroquinolone or TMP-SMX

PROSTATITIS

–> Fluoroquinolone or TMP-SMX

Question 11

Drug of choice for intra-abdominal infections

Answer 11

• Ticarcillin + Clavulanate

Question 12

drug of choice for clostridium difficile infection

Answer 12

Intra-abdominal infections

Metronidazole (moderate)

Vancomycin (Severe)

Question 13

Treamtnet for community acquired bacterial meningitis

Answer 13

Ceftriazone or cefotaxime (3rd gen of cephlosporin)

–> can add Vancomycin

Question 14

Drugs of choice for neonatal meningitis

Answer 14

younger then 2 months

• Ampicillin + cephalosporin

–> can add gentamicin

Question 15

treatment of sepsis sysndrome

Answer 15

3rd or 4th gen Cephalosporin (CEFEPIME)

–> can add Vancomycin

Question 16

drugs of choice for endocarditis

Answer 16

Empiric

–> Ceftriaxone + vancomycin

Question 17

treatment of fever + neutropenia

Answer 17

• Empriric

–> ciprofloxacin + amoxicillin/Clavulanate

Question 18

Treatment for multi-drug resistance enterococci

Answer 18

• Linezolid, Daptomycin, or Tigecycline

Question 19

Multi drug resistance to gram-negative bacteria

Answer 19

ESBL = Carbapenem (Imipenem or meropenem)

Carbapenemases = Polymyxin B, Tigecycline or Colistin