Antibiotics

Question 1

What is the MOA for Flucloxacillin?

Answer 1

-Penicillin’s prevent cross linkage of polymer chains.
- Does so by binding to penecillin binding proteins (pbp).
-These chains regulate bacterial cell division and protect the cell.
-If cell not protected, cell wall synthesis cannot take place.
-And further bacterial growth in prevented.

Question 2

How does Flucloxacillin differ from other penicillins?

Answer 2

It cannot be broken down by penicillinase (like other penicillins), an enzyme that inactivates the antibiotic.

Question 3

What is the dose of Flucloxacillin?

Answer 3

-Moderate infection: 1g 4x per day.
-30 mins before food.
-Max no. 28 doses over 7 days.

Question 4

What are the side effects of Flucloxacillin?

Answer 4

-Nausea
-Vomiting
-Breathing difficultly
-Anaphylaxis

Question 5

What drug interactions are there with Flucloxacillin?

Answer 5

Anticoagulants- Antibiotics alter INR.
Oestrogen- Antibiotics decrease the effectiveness of the pill.

Question 6

What are the contraindications for Flucloxacillin?

Answer 6

-Hypersensitivity to Penicillin’s.
-Poor hepatic and renal function.

Question 7

What is the MOA of Erythromcin?

Answer 7

-Blocks bacterial cell’s ability to make new proteins by binding to ribosomes responsible for protein synthesis.
-Blocking proteins= no chemical reactions can take place, meaning cells are unable to function.
-No new cells.

Question 8

Erythromycin dose:

Answer 8

Moderate infection: 1g 4x per day.
With or without food.
Max. dose : 28 over a week.

Question 9

Erythromycin side effects:

Answer 9

-Nausea/vomiting
-Stomach irritation
-Diarrhoea
-Colitis
- Rashes

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Question 10

What interactions are there with Erythromycin?

Answer 10

Anticoagulants: Macrolides increase conc. of anticoags in blood (increase blood toxicity).
Decreased effectiveness of contraceptive pill.

Question 11

What are the contraindications for Erthromycin?

Answer 11

Hypersensitivity.
Hepatic and renal function.