Antibiotics Flashcards
- Substances that inhibit the growth of or kill
bacteria and other microorganisms
(viruses, fungi, protozoa and ricketssiae)
Antibacterials or antibiotics
Chemicals produced by one
kind of microorganism that inhibits the
growth of or kills another
Antibiotics
Natural – “moldy bread”
Manufactured
Antibacterials:
- Inhibit the growth of bacteria
Bacteriostatic
Kills bacteria
Bactericidal
Mechanism of antimicrobial action
Inhibition of bacterial cell wall synthesis
Alteration of membrane permeability
Inhibition of Protein Synthesis of bacterial
RNA and DNA
Interference with the metabolism within
the cell
Pharmacokinetics of antibiotics
drugs are not highly protein bound
Eliminated mainly through urination
Pharmacodynamics of antibiotics
Effective when the drug concentration remains constantly above the MEC during the dosing interval Once-daily antibacterial dosing are effective also
Use of Antibiotic
Combinations 2 effects
additive and potentiative
SE of antibiotics
Nausea, Vomiting and Diarrhea Secondary Infection Allergies Nephrotoxicity Hepatotoxicity Ototoxicity
Natural antibacterial agent obtained from mold genus Penicillium Used in World War II “Miracle Drug” Discovered by Fleming SE: hypersensitivity and superinfection
Penicillins
Natural antibacterial agent obtained from mold genus Penicillium Used in World War II “Miracle Drug” Discovered by Fleming SE: hypersensitivity and superinfection
Penicillins
First to be administered orally and by injection
Painful to be administered IM and has short
duration
penicillin G
First to be administered orally and by injection
Painful to be administered IM and has short
duration
penicillin G
(longer duration of action and
less painful)
procaine penicillin
Effective against mild to moderate infections
penicillin V
Treats both gram positive and gram negative
bacteria
Costlier than penicillin
Effective against E.Coli, H. Influenzae, Shigella
Dysenteriae and Salmonella
Broad spectrum Penicillins
broad spectrum penicillin example drugs
ampicillin
amoxicillin
Antistaphylococcal Penicillins
Not effective against gram negative organisms
Less effective than Pen G against gram positive
microorganisms
Penicillinase-Resistant Penicillins
Penicillinase-Resistant Penicillins examples
cloxacillin
oxacillin
Anti-pseudomonal penicillins
Effective against Pseudomonas Aeruginosa
Similar action to Aminoglycosides but less toxic
Extended spectrum penicillins
Extended spectrum penicillins
piperacillin sodium
piperacillin-tazobactam (Piptaz)
Extended spectrum penicillins
piperacillin sodium
piperacillin-tazobactam (Piptaz)
NX when giving penicillins
Check for signs of superinfections (stomatitis,
genital discharge and anal or genital itching)
Check for allergic reactions
Check for bleeding
Dilute the antibiotic for IV use
Take the medication with food
When a broad spectrum antibiotic is
combined with beta-lactamase inhibitor,
the resulting antibiotic inhibits the
bacterial beta-lactamase
beta-lactamase inhibitors
beta-lactamase inhibitors drugs
clavulanic acid, sulbactam, tazobactam
Amoxicillin + Clavalunic Acid =
Augmentin
Ampicillin + Sulbactam
Unasyn
Piperacillin + Tazobactam
Zosyn
Ticarcillin + Clavulanic Acid
Timentin
Action: same as Penicillin
Active against gram positive and gram
negative and resistant to betalactamase
SE: nephrotoxicity
Cephalosporins
Efective against gram-positive and gram
negative bacteria, Streptococci and mostly
staphylococci
first gen Cephalosporins
first gen Cephalosporins drugs
cephalexin, cefazolin sodium
Same effectiveness as first generation.
Possess a broader spectrum against other gramnegative bacteria:
2nd gen Cephalosporins
2nd gen Cephalosporins drugs
cefaclor (Ceclor), cefoxitin sodium, (Mefoxitin),
cefuroxime(Zinacef)
Same effectiveness as the first and second
generations
Less effective against gram-positive bacteria
3rd gen Cephalosporins