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Farma 2 > Antibiotice 3 > Flashcards

Antibiotice 3 Flashcards

1
Q

Anti TBC majore

A

rifampicina
izoniazida
etambutol
-streptomicina

pirazinamida

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2
Q

Anti TBC minore

A 
fluorochinolone (moxifloxacina, gatifloxacina)
etionamida
acid p aminosalicilic
cicloserina
kanamicina
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3
Q

Anti leproase

A

rifampicina
dapsona
clofazimina

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4
Q

Antiseptice urinare

A

metenamina

nitrofurantoina

fosfomicina

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5
Q

MA metenamina

A

la ph sub 5,5 este hidrolizata in formaldehida si nh4+, formaldehida denatureaza proteinele bacteriene si acizii nucleici

nu se asociaza cu substante cu risc de cristalurie ca sulfonamidele

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6
Q

MA nitrofurantoina

A

intracelular este redusa de flavoproteinele bacteriene cu formare de radical cu reactivitate mare, care inhiba ciclul citratului, sinteza de ARN si ADN

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7
Q

MA fosfomicina

A

inhiba sinteza peptidoglicanului, componenta a peretelui celular bacterian

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8
Q

Antiseptice intestinale

A 
furazolidona
nifuroxazid
clorchinaldol
rifaximina alfa
fidaxomicina
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9
Q

MA furazolidona

A

derivat de nitrofuran, impiedica transcriptia si replicarea ADN ului prin formarea unor legaturi intracatenare

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10
Q

MA nifuroxazid

A

intracelular este redusa de flavoproteinele bacteriene cu formare de radical cu reactivitate mare, care inhiba ciclul citratului, sinteza de ARN si ADN

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11
Q

MA Clorchinaldol

A

proprietatea de a chela anumiti ioni care functioneaza ca si cofactori enzimatici

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12
Q

MA rifaximina alfa

A

inhiba sinteza de ARN prin inhibarea polimerazei ADN dependente

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13
Q

MA flidaxomicina

A

inhiba sinteza de ARN prin legarea de arn polimeraza

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14
Q

Sulfonamide MA

A

analog al acidului para-amino-banzoic (din structura acidului folic) intra in competitie cu acesta si inhiba
DIHIDROPTEROAT sintaza —inhiba sinteza bacteriana de acid folic

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15
Q

Trimetoprim MA

A

inhiba dihidrofolat reductaza

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16
Q

Sulfonamide cu actiune locala

A

sulfacetamid
mafenid
sulfadiazina argentica

17
Q

Sulfonamide cu actiune sitemica

A

sulfafurazol
sulfatiazol
sulfapiridina (sulfazalazina descompusain intestin in sulfapiridina si acid 5 aminosalicilic)
sulfadimina

sulfametoxazol
sulfafenazol

sulfametoxidiazina
sulfadimetoxina
sulfametoxipiridazina

18
Q

Sulfonamide cu actiune locala si sistemica

A

salazosulfpiridina

ftalisulfatiazol

19
Q

Tratament toxoplasmoza

A

sulfadiazina+primetamina

20
Q

Co-trimoxazol

A

sulfametoxazol+trimetoprim

21
Q

MA chinolone si fluorochinolone

A

pe germeni gram + impiedica sinteza ADN ului prin inhibarea topoizomerazei 4 - impiedica separarea celor doua noi catene in urma replicarii

pe germeni gram - inhiba ADN giraza bacteriana(topoizomeraza 2) enzima ce impiedica supraspiralizarea catenei ADN

22
Q

Chinolone GI

A

acid nalidixic

23
Q

fluorochinolone GII

A 
norfloxacina
ciprofloxacina
ofloxacina
lomefloxacina
pefloxacina
24
Q

G III fluorochinolone

A

levofloxacina

25
Q

G IV fluorochinolone

A

moxifloxacina

Farma 2 (6 decks)

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