Antibiotic prescription – combining micro + antibiotic knowledge Flashcards
Which of these bacteria (from the table) are classically associated with the following infections?
CELLULITIS
Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis
Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia
Grp A strep, staph aureus
Which of these bacteria (from the table) are classically associated with the following infections?
* Infected chronic diabetic ulcer
* Pressure sore
Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis
Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia
mixture of Gram positive and Gram negative organisms
new onset infection – suspect Staph aureus / Streptococci
Which of these bacteria (from the table) are classically associated with the following infections?
CAP – community acquired pneumonia
Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis
Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia
‘typical bacteria’ – Streptococcus pneumoniae (+ve), Haemophilus influenzae (-ve)
Most impt is top 2
‘atypical bacteria’ – Mycoplasma pneumoniae, Chlamydia pneumoniae, Legionella pneumophila
Others – Staphylococcus aureus (esp. post influenza), Klebsiella pneumoniae
Don’t forget about viruses - Influenza
Which of these bacteria (from the table) are classically associated with the following infections?
Gastroenteritis
Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis
Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia
- Salmonella
(non typhi,non paratyphi) - Shigella
- Vibrio
- Campylobacter
Which of these bacteria (from the table) are classically associated with the following infections?
Enteric fever / typhoid fever
Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis
Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia
Salmonella typhi
Salmonella paratyphi
Which of these bacteria (from the table) are classically associated with the following infections?
- Fournier’s gangrene/ Type 1
necrotizing fasciitis
- Type 2 NF
Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis
Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia
Type 1: Polymicrobial
Type 2: Group A Strep
Which of these bacteria (from the table) are classically associated with the following infections?
neonatal sepsis / neonatal meningitis
Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis
Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia
Beta haem Strep B
When you start working, expect to get such calls from the micro lab staff :
- “Hello dr, we have isolated gram positive cocci in clusters, in Tan See See’s
blood culture.” - “Hello dr, you have asked for urgent gram stain on Ng Ann Bee’s CSF, we could see gram positive cocci in pairs”
- “Hello dr, we have isolated gram negative bacilli in A Gaganathan’s blood culture taken from the central line”
- “Hello dr, you have asked for urgent gram stain on Ali Bin Hasan’s knee aspirate, we could see gram positive cocci in chains”
a. How does this information help you?
b. Does this gram stain info influence which antibiotic you would prescribe?
a. sterile sites have microbes. BAD, will spread
b. Check best guess/empirical AB used
Which of these bacteria (from the table) are classically associated with the following infections?
bacterial pharyngitis
Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis
Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia
grp A strep
EXAM: Broadest to narrowest AB spectrum
- Broadest: carbapenem (big dad): ALL gram + and gram - except CRE (Carbapenem-Resistant Enterobacterales)
- Tazocin: unresolved even with S to extended spectrum beta lactamase (ESBL) and Amp C, CRE resistant to it
- Augmentin and ceftriaxone (narrow): All + ok, -ve CRE, ESBL, Amp C, pseudomonas aeruginosa resistant to it