Antibiotic prescription – combining micro + antibiotic knowledge Flashcards

1
Q

Which of these bacteria (from the table) are classically associated with the following infections?
CELLULITIS
Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis

Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia

A

Grp A strep, staph aureus

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2
Q

Which of these bacteria (from the table) are classically associated with the following infections?
* Infected chronic diabetic ulcer
* Pressure sore

Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis

Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia

A

mixture of Gram positive and Gram negative organisms
new onset infection – suspect Staph aureus / Streptococci

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3
Q

Which of these bacteria (from the table) are classically associated with the following infections?
CAP – community acquired pneumonia

Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis

Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia

A

‘typical bacteria’ – Streptococcus pneumoniae (+ve), Haemophilus influenzae (-ve)

Most impt is top 2
‘atypical bacteria’ – Mycoplasma pneumoniae, Chlamydia pneumoniae, Legionella pneumophila

Others – Staphylococcus aureus (esp. post influenza), Klebsiella pneumoniae
Don’t forget about viruses - Influenza

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4
Q

Which of these bacteria (from the table) are classically associated with the following infections?
Gastroenteritis

Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis

Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia

A
  • Salmonella
    (non typhi,non paratyphi)
  • Shigella
  • Vibrio
  • Campylobacter
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5
Q

Which of these bacteria (from the table) are classically associated with the following infections?
Enteric fever / typhoid fever

Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis

Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia

A

Salmonella typhi
Salmonella paratyphi

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6
Q

Which of these bacteria (from the table) are classically associated with the following infections?
- Fournier’s gangrene/ Type 1
necrotizing fasciitis
- Type 2 NF

Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis

Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia

A

Type 1: Polymicrobial
Type 2: Group A Strep

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7
Q

Which of these bacteria (from the table) are classically associated with the following infections?
neonatal sepsis / neonatal meningitis

Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis

Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia

A

Beta haem Strep B

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8
Q

When you start working, expect to get such calls from the micro lab staff :

  • “Hello dr, we have isolated gram positive cocci in clusters, in Tan See See’s
    blood culture.”
  • “Hello dr, you have asked for urgent gram stain on Ng Ann Bee’s CSF, we could see gram positive cocci in pairs”
  • “Hello dr, we have isolated gram negative bacilli in A Gaganathan’s blood culture taken from the central line”
  • “Hello dr, you have asked for urgent gram stain on Ali Bin Hasan’s knee aspirate, we could see gram positive cocci in chains”

a. How does this information help you?
b. Does this gram stain info influence which antibiotic you would prescribe?

A

a. sterile sites have microbes. BAD, will spread
b. Check best guess/empirical AB used

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9
Q

Which of these bacteria (from the table) are classically associated with the following infections?
bacterial pharyngitis

Gram positive:
- Staphylococcus aureus
- Beta-haemolytic Strep A (grp A)
- Beta-haemolytic Strep B (Grp B)
- Streptococcus pneumoniae
- ‘Other Streps’:
Strep mitis, Strep bovis, viridans Strep, Strep anginosus (These all belong in the family of alpha-haemolytic Strep)
- Enterococcus (‘faecal Strep’)
- Listeria
- Corynebacterium diphtheriae
- Clostridium perfringens, Clostridium tetani, Clostridium botulinum, Clostridium difficile
- Bacillus anthracis

Gram negative:
- Coliforms: E coli, Klebsiella pneumoniae, Proteus, Enterobacter, Morganella
- Salmonella, Vibrio, Shigella, Campylobacter
- Pseudomonas aeruginosa
- Haemophilus influenzae
- Helicobacter pylori
- Neisseria meningitidis, Neisseria gonorrhea
- Bacteroides fragilis
- Burkhholderia pseudomallei
- Stenotrophomonas maltophilia

A

grp A strep

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10
Q

EXAM: Broadest to narrowest AB spectrum

A
  • Broadest: carbapenem (big dad): ALL gram + and gram - except CRE (Carbapenem-Resistant Enterobacterales)
  • Tazocin: unresolved even with S to extended spectrum beta lactamase (ESBL) and Amp C, CRE resistant to it
  • Augmentin and ceftriaxone (narrow): All + ok, -ve CRE, ESBL, Amp C, pseudomonas aeruginosa resistant to it
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