Antibiotic: Interfere w/ DNA Synthesis Flashcards
What 2 enzymes to FQs inhibit?
DNA Gyrase + Topoisomerase IV
This enzyme prevents DNA from uncoiling to allow transcription and replication.
DNA Gyrase
This enzyme doesn’t allow replicated DNA to separate to its respective daughter strands/cells.
Topoisomerase IV
What is the age restriction for FQs?
Pt must be 18+
What are the ADRs of FQs?
- Cartilage toxicity, joint swelling, tendonitis
2. Increase muscle weakness in pts wit hMG
What was the first commercially available FQ?
Ciprofloxacin
What are the 3 types of 2nd gen. FQs?
- Ciprofloxacin
- Norfloxacin
- Ofloxacin
Name a 3rd generation FQ.
Levofloxacin
Levofloxacin has increased ______ which penetrates the cornea to aqueous readily.
solubility
What are the 3 types of 4th gen. FQ?
- Moxifloxacin
- Gatifloxacin
- Besifloxacin
What are the 2 medications associated with Moxifloxacin?
Moxeza and Vigamox
Moxeza is good for what age? What is the pregnancy category?
4mo. and older
Preg. Cate. C
Moxeza contains an xanthan gum vehicle and is ___x greater than Vigamox
1.8x
Vigamox is good for what age?
1 yo +
Gatifloxacin is Zymaxid. What pregnancy category is it?
Pregnancy Cat. C