Antibiotic: Interfere w/ DNA Synthesis Flashcards

1
Q

What 2 enzymes to FQs inhibit?

A

DNA Gyrase + Topoisomerase IV

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2
Q

This enzyme prevents DNA from uncoiling to allow transcription and replication.

A

DNA Gyrase

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3
Q

This enzyme doesn’t allow replicated DNA to separate to its respective daughter strands/cells.

A

Topoisomerase IV

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4
Q

What is the age restriction for FQs?

A

Pt must be 18+

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5
Q

What are the ADRs of FQs?

A
  1. Cartilage toxicity, joint swelling, tendonitis

2. Increase muscle weakness in pts wit hMG

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6
Q

What was the first commercially available FQ?

A

Ciprofloxacin

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7
Q

What are the 3 types of 2nd gen. FQs?

A
  1. Ciprofloxacin
  2. Norfloxacin
  3. Ofloxacin
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8
Q

Name a 3rd generation FQ.

A

Levofloxacin

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9
Q

Levofloxacin has increased ______ which penetrates the cornea to aqueous readily.

A

solubility

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10
Q

What are the 3 types of 4th gen. FQ?

A
  1. Moxifloxacin
  2. Gatifloxacin
  3. Besifloxacin
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11
Q

What are the 2 medications associated with Moxifloxacin?

A

Moxeza and Vigamox

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12
Q

Moxeza is good for what age? What is the pregnancy category?

A

4mo. and older

Preg. Cate. C

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13
Q

Moxeza contains an xanthan gum vehicle and is ___x greater than Vigamox

A

1.8x

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14
Q

Vigamox is good for what age?

A

1 yo +

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15
Q

Gatifloxacin is Zymaxid. What pregnancy category is it?

A

Pregnancy Cat. C

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16
Q

Besifloxacin (i.e. Besivance) is the DOC for what?

A

Corneal Ulcers

17
Q

The bacterial resistance to Besifloxacin is ___ due to no systemic counterpart.

A

low

18
Q

What are the ADRs for Besifloxacin?

A
  1. Hyperemia
  2. Blurred Vision
  3. Pain
  4. Irritation
  5. HA