Antibacterials Flashcards
1
Q
What is dapsone mechanism of action?
A
Systemic: Antibacterial (antileprosy agent): a sulfone, is bacteriostatic and probably acts by a mechanism similar to that of the sulfonamides, interfering with folate synthesis. Both have a similar range of antibacterial activity and are antagonized by para-aminobenzoic acid.
Dermatitis herpetiformis suppressant-Mechanism is unknown, but not due to dapsone’s bacteriostatic effect. Dapsone may act as an enzyme inhibitor or oxidizing agent. In addition, it has numerous immunologic effects (e.g., immunosuppression), which most likely account for its suppression of dermatitis herpetiformis.
