antibacterial drugs targeting the cell envelope Flashcards
what does trans glycosylation and transpeptidation involve
they are part of peptidoglycan synthesis 1st one is polymerisation of glycan strands the second one is cross linking between glycan strands.
what catalyses both reactions in the synthesis
penicillin binding proteins which are bi functional with 2 separate domains and they are membrane associated.
what are the two types of antibiotic classes that interfere with these final stages
beta-lactams, glycopeptides
how does beta lactam work
affects transpeptidation by blocking cross linking of peptide side chains
what do peptidoglycan hydrolases do
cleave PG during normal growth and they are not inhibited by beta lactams so they continue to hydrolyse and lead to a weak PG
what are some side affects of beta lactams
hypersensitivity, anaphylactic shoch after injection.
