antibacterial drugs Flashcards
When looking at the ideal antibiotics what factors do we consider
- Spectrum of action
- Effect on the patient’s cells
- Route of administration
- Duration of action
- Route of excretion/ metabolism
- Interaction with other drugs
- Side effects
- Resistance
What do we mean by effect on bacteria
bacterostatic vs bactericidal
What do we mean by bacterostatic
Antibiotic stops replication of bacteria
What do we mean by bactericidal
Antibiotics kills bacteria
Do we prefer bactericidal or bacterostatic effect on bacteria
bactericidal
What do we mean by spectrum of action
Narrow vs broad
What do we mean narrow spectrum of action
Antibiotic strops replication or kills a narrow range of bacterial species
What do we mean broad spectrum of action
Antibiotic strops replication or kills a wide range of bacterial species
Do we prefer a narrow or broad spectrum of action
It depends on if the broad spectrum will harm our healthy bacteria
Do we want the antibiotic to affect the patients cells
no
What can happen if antibiotics affect the patents cells
- Allergies
- Autotoxic
- Can damage the kidneys
- Can damage the lover
Do want the antibiotic to have a short or long duration of action
Long so need to take it at larger intervals
What actions can antibiotics inhibit to affect bacterias life
- DNA replication
- Ribosome funciton
- Folate synthesis
- Cell wall synthesis
Give examples of antibiotics that affect DNA replication
Metronidazole
Give examples of antibiotics that affect Ribosome function
Macrolides
Tetracycline
Aminoglycosides