ANTIARRYTHMICS

Question 1

CLASS 1 ANTI-ARRYTHMICS

Answer 1

SODIUM CHANNEL BLOCKER
-on ischemic cell

A1- PROLONG AP
A2- SHORTENS AP (selective)
A3- NO EFFECT AP

PHASE 0

Question 2

CLASS 2 ANTI-ARRYTHMICS

Answer 2

B ADRENORECEPTOR BLOCKER

reduction on both Na and Ca

PR INTERVAL

Phase 4

Question 3

CLASS 3 ANTI-ARRYTHMICS

Answer 3

K CHANNEL BLOCKER

Increase QT interval

Phase 3

Question 4

CLASS 4 ANTI-ARRYTHMICS

Answer 4

Calcium channel blocker
(NON- DYHYDROPYRIDINE)

Decrease velocity
Prolongs PR

Question 5

PROCAINAMIDE

Answer 5

A1- blocks INa/k

Arrythmia after MI

SE: LUPUS LIKE

Question 6

DISOPYRAMIDE

Answer 6

A1- blocks INa/ K

SE: MARKED ANTIMUSCARINIC

Question 7

QUINIDINE

Answer 7

A1- blocks INa/ K

ANTI MALARIAL

SE:
TORSADES
CINCHONISM (Headache, tinnitus, vertigo)
ITP

Question 8

SODIUM LACTATE

Answer 8

REVERSE DRUG-INDUCED arrythmia

Question 9

LIDOCAINE

Answer 9

1B- block INa (no Ik)

DOC VENTRICULAR ARRYTHMIA POSTMYOCARDIAL

SE: agranulocytosis

PHENYTOIN, TOCAINIDE, MEXILETINE

Question 10

FLECAINIDE

Answer 10

1c- Prolongs QRS

REFRACTORY ARRYTHMIA

DO NOT USE IN MI

PROPAFENONE, ENCAINIDE

Question 11

ESMOLOL

Answer 11

2- SHORTEST ACTING

PERIOPERATIVE ARRYTHMIA

Question 12

DOFETILIDE

Answer 12

3- selective block Ik

ATRIAL FIBRILLATION

SE: TORSADES

Question 13

SOTALOL

Answer 13

3- Ik block and b adrenergic block

ATRIAL FIBRILLATION
SUPRAVENTRICULAR TACHYCARDIA

SE: TORSADES

Question 14

AMIODARONE

Answer 14

3- STRONG Ik block

REFRACTORY ARRYTHMIA

SE:
MICROCRYSTALS IN SKIN AND EYE
THYROID FXN
PULMONARY FIBROSIS

MOST EFFICACIOUS
LONGEST HALF LIFE

Question 15

ADENOSINE

Answer 15

Misc- inc diastolic Ik
Reduce Ica

PAROXYSMAL SUPRAVENTRICULAR TACHY