Antiarrhythmic Drugs

Question 1

Procainamide

Answer 1

Na CB Class 1A

Atrial, SPVT, VT arrhythmia
(nalui: for shot term txt for SPVT)

Oral, iv, im
The least Anticolinergic

A/E Lupus Erythematosus like syndrome(severe auto immune disease)
TDP (due to NAPA) check Nalui

DDI Amiodarone, cimetidine, 2d6 IA
antidepressant, macrolide AB

Question 2

Quinidine

Answer 2

Na CB 1A

SPVT & V Arrhythmia

PO ALWAYS

A/E Cardiotox due to anti choli effect (increase SA automaticity, AV conduction)

Diarhea

TDP

HYPO-, GI, Cinchonsim
reash, mucle weakness

DDI: Amidarone,DIG,
2d6 IA
antidepressant, macrolide AB

Question 3

Disopyramide

Answer 3

Na CB 1A
only to supress V ARR

STRONG NEGATIVE INTROPIC EFFECT. worse the HF

Highest anticoli effect

DDI : Amiodarone, BB (Why?) Macrolide AB