antianginals 56 Flashcards
Nitroglycerin (Minitran, Nitrostat)
nitrate (“nit”)
“denitrated” 2x in liver, from trinitrate to mononitrate (less active: 1st pass effect)
oral, sublingual
Isosorbide Dinitrate (Isordil)
nitrate (“nit”)
Nifedipine (Procardia XL)
calcium channel blocker (CCB)
act largely in arterial tissue
reduction in after load
vasospasm in a coronary artery can be reversed
Amlodipine (Norvasc)
calcium channel blocker (CCB)
long-acting
Verapamil (Isoptin SR, Calan)
calcium channel blocker (CCB)
act largely in the heart
reduce cardiac rate and contractility
Diltiazem (Cardizem)
calcium channel blocker (CCB)
act largely in the heart
reduce cardiac rate and contractility
Propranolol (Inderal-LA)
β-1 and2 Adrenergic Blocker
Nadolol (Corgard)
β-1 and 2 Adrenergic Blocker
Timolol
β-1 and 2 Adrenergic Blocker
Atenolol (Tenormin)
β1 (only)-Adrenergic Blocker
Metoprolol (Toprol-XL) New Class
β1 (only)-Adrenergic Blocker
Ranolazine (Ranexa)
new class: FA oxidation inhibitor
tx for chronic stable angina (in combo or alone)
-will not dec. BP
Selective inhibition of increased “late” inward-directed Na+ current caused by MI
allows for better Na+/Ca2+ exchange across myocardial cell membranes which reduces ischemia-induced calcium overload and related oxygen demand
used for chronic stable angina (alone or in combo)
(thought to be MOA originally: Shifting the source of fuel used by the myocardium from fatty acid to glucose, which demands less oxygen)-not so much
nitrate SEs
orthostatic hypotensive symptoms
throbbing headache from pulsating meningeal vasodilation
too much reflex increase in heart rate and contractility which can compromise the therapeutic goal.
systemic sodium and water retention.
??? can develop to nitrates
can also get rebound ???
tolerance (in part due to vascular fluid retention- offsets preload)
angina
can get potentially fatal interactions with nitrates and ???
Viagra and other cGMP- inactivating Phosphodiesterase-5 inhibitors used to treat erectile dysfunction
severe decrease in BP