Antianginal Drugs Flashcards
it is an inhaled drug that is very short acting but it is not popular due to its bad odor
amyl nitrate
short acting and fast onset drugs
amyl nitrate, nitroglycerin (sublingual and intravenous)
mainstay of antianginal treatment; can be taken sublingually at home, or intravenously in the hospital, both are very short acting
nitroglycerin (sublingual and intravenous)
long acting organic nitrites and nitrates?
Nitroglycerin (Buccal Trans-mucosal), Nitroglycerin (Oral), Nitroglycerin (transdermal) Isosorbide dinitrate(sublingual), isosorbide dinitrate (Oral), isosorbide mononitrate(Oral), Erithrityl tetra-nitrate (Sublingual), Erithrityl tetra-nitrate (oral), Penta-erythritol tetra-nitrate (PETN)
out of the long acting nitroglycerin, which one has the fastest onset of action
Nitroglycerin (Buccal Trans-mucosal)
PETN is special in that it is
explosive
is taken in the cheek, it is fast onset but can last for several hours
buccal nitroglycerin
has slower onset but is longer lasting than the IV, buccal, or sublingual formulations
oral nitroglycerine
good for patients with nocturnal angina
transdermal nitroglycerin
popular for angina pectoris
nitrates and nitrites
Erithrityl tetranitrate comes in how many forms
sublingual and oral forms
Pentaerythritol Tetra-nitrate comes in what form
oral form
isosorbide comes in what forms
isosorbide dinitrate comes in sublingual and oral forms and isosorbide mono-nitrate comes only in oral form. both are slow onset and long acting
adsorbed on lactose, colloidal silicone dioxide and silicone medical fluid
transdermal nitroglycerin
a layer of what ensures the attachment of transdermal nitroglycerin to skin
a layer of silicone adhesive
non selective beta 1 and 2 adrenergic receptor blockers first generation
nadolol and propranolol
membrane stabilizing property, which is essentially a sodium channel blocking affect which makes it effective as an antiarrhythmic
propranolol, metoprolol
long acting first generation non selective beta blocker
nadolol
non selective B- adrenergic receptor blockers are not useful for
these drugs are not useful in the treatment of prinzmetal’s angina because of the possible constriction of coronary arteries due to un-opposed effect of alpha-1 adrenergic receptor activation; nadolol and propranolol
have a profound effect on vasodilation, and are useful for angina. They have no effect on AV node conduction, and are not useful as antiarrhythmics
nifedipine and amlodipine
have an affect on vasodilation, as well as controlling AV node conduction. Therefore they are good for angina, as well as arrhythmia
diltiazem and verapamil
