Antianginal Drugs Flashcards
What are stable/classic angina cases usually caused by?
coronary atherosclerotic occlusion
What is another name/term used for stable angina?
angina of effort or exercise
What is Prinzmetal angina often commonly referred to as?
vasospastic or variant angina
What is Prinzmetal Angina commonly caused by?
an event which leads to reversible decrease in coronary blood flow
What are drug strategies to treat stable angina?
reduce O2 requirement, reduce TPR, CO or both
(nitrates, CCBs, and beta blockers)
What are the drug strategies to treat vasospastic angina?
(nitrates and CCBs)
Nitroglycerin S/E?
flushing, headache, orthostatic hypotension
What type of Beta blockers are good for use in treating angina of effort?
carvediolol
Which type of CCB’s are important for vasospastic angina?
Dipines
What are drugs that decrease mortality in patients with stable angina?
aspirin, nitroglycerin, and beta blockers
What is the preferred drug for acute management of both stable and vasospastic angina?
Nitroglycerin
What is the MOA of Ranolazine?
Blocks late Na+ currents in cardiac myocytes and dec. Ca2+ accumulation ultimately leading to reduced O2 consumption and blocks K+ channels
Does Ranolazine have effects on HR and BP?
no
What are the S/E of Ranolazine?
constipation
nausea
inc. QT
headache
Dizziness
What is an indication of using Ranolazine?
2nd line treatment for refractory angina
