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Farmacologia Dr Prieto > Antiagregantes, ACOA y fibrinolíticos > Flashcards

Antiagregantes, ACOA y fibrinolíticos Flashcards

1
Q

MEcanismo de acción AAS

A

Bloqueo de tromboxano A2 plaquetario permanente (por toda la vida de plaquetas de 7-10 dias)

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2
Q

EA AAS

A

Dispepsia, ulcera gástrica, HTD, disminución de perfusión renal, sx Reye

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3
Q

Mecanismo de acción Dipiridamol

A

Aumenta AMPc intracelular en plaquetas interfiriendo en su función

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4
Q

Antagonistas del receptor P2Y12

A

Clopidogrel, prasugrel

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5
Q

Mecanismo de acción Antagonistas del receptor P2Y12

A

Bloqueo receptor plaquetario P2Y12

Clopidogrel y prasugrel –> bloqueo irreversible

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6
Q

Inhibidores de glucoproteína IIb/IIIa

A

Abciximab, eptifibatida

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7
Q

Mecanismo de acción Inhibidores de glucoproteína IIb/IIIa

A

Inhibición de ruta común final de agregación plaquetaria bloqueando firbinógeno y FvW

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8
Q

EA Inhibidores de glucoproteína IIb/IIIa

A

Riesgo de hemorragia y trombocitopenia

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9
Q

Antagonistas de vitamina K

A

Anticoagulantes indirectos

warfarina y acenocumarina

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10
Q

Mecanismo de acción Antagonistas de vitamina K

A

Inhibición de carboxilación de factores dependientes de vit K (II, VII, IX, X, protenia C y S)

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11
Q

EA Antagonistas de vitamina K

A

Riesgo de hemorragia, teratogenicidad, necrosis cutánea

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12
Q

Anticoagulantes directos

A

Dabigatrán, rivaroxaba, apixaban

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13
Q

Mecanismo de acción Anticoagulantes directos

A

Dabigatrán –> Bloqueo reversible de sitio activo de trombina
Rivarozaba, apixaban –> inhibición factor Xa libre

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14
Q

ACOA parenterales

A

Heparina no fraccionada
HBPM (enoxaparina, nadroparina
Fondaparinux

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15
Q

Mecanismo de acción ACOA parenterales

A

HNF –> estimula actividad antitrombina

HPBM y fondaparinux –> inhibición factor Xa

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16
Q

Fibrinolíticos

A

1a generación –> Uriocinasa, estreptocinasa
2a generaciom –> alteplasa
3a generacion o recombinantes –> tenecteplasa y reteplasa.

17
Q

Mecanismo de acción Fibrinolíticos

A

Unen a fibrina y activan plasminógeno más rápido.

Farmacologia Dr Prieto (11 decks)

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