Anti-Virals Flashcards
[Abreva Docosanol] MOA
[Long chain alcohol] that disturbs HSV cell membrane –> DEC HSV entry
Most of theHerpes Family Drugs are _______. What makes Valacyclovir/ValGangcyclovir unique?
Anti-Herpes = Nucleoside Analogs
Val = added Valine (Proprodrug) –> INC PO bioavailability
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/462/240/a_image_thumb.png?1460940485)
Describe how the Herpes family may become drug resistant. What does this mean for outcome?
[Viral Thymidine Kinase] adds the first phosphate to Acyclovir –> [Acyclovir monophosphate] (human enzymes add the other 2).
Herpes virus with mutated TK –> Drug Resistance.
but…
Mutated TK Herpes –> viral weakness and so aren’t as common
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/462/346/a_image_thumb.png?1461380279)
Acyclovir MOA
[Acyclovir TriPhosphate] is a Guanosine analog that incorporates into replicating viral DNA –> Halts synthesis
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/462/593/a_image_thumb.png?1461380411)
Acyclovir Indication (2)
HSV
Zoster (shingles)
(IV for encephalitits)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/462/775/a_image_thumb.png?1461380584)
Acyclovir SE (3)
- [Renal Damage w/rapid infusion (interstitial nephritis vs. crystalline nephropathy] (check pt hydration status)
- HA
- GI sx
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/462/832/a_image_thumb.png?1461380845)
How many DDI does Acyclovir have?
4 serious interactions with abx
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/463/058/a_image_thumb.png?1460941010)
Ganciclovir MOA
Herpes Guanosine analog, first phosphorylated by [Herpes UL97 kinase]–> Chain Termination
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/463/122/a_image_thumb.png?1461381139)
Ganciclovir Indication (5)
- [CMV Pizza Pie Retinitis - PO]
- [CMV Post Transplant Px - IV]
- [HHV6 and 7 Roseola]
- [HHV8 Kaposi Sarcoma]
- EBV
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/463/123/a_image_thumb.png?1461381275)
Ganciclovir SE (4)
u throw Bones in the Grass, u get a R**ash. U ThrowUp in the Grass and then u Pass
- [Bone Marrow Suppression]
- Rash
- NVD
- Neurotoxicity (rare)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/463/124/a_image_thumb.png?1461381381)
How many DDI does Ganciclovir have?
4 serious interactions with abx
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/463/125/a_image_thumb.png?1460941096)
Foscarnet MOA
Fos = phos
[pyrophosphate binding site] blocker –> Directly inhibits [Viral DNA polymerase]
NOT FIRST LINE TX
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/463/475/a_image_thumb.png?1461381665)
Foscarnet Indication (5)
“Gonna play CHER Voice in my Fas Car”
- [HSV-Resistant]
- [CMV Pizza pie Retinitis - IV]
- Varicella Zoster
- EBV
- [HHV6 & 7 Roseola]
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/463/476/a_image_thumb.png?1460941685)
Foscarnet SE (4)
You’ll be saying AMEN, taking Fos For 2 long!
- NEPHROTOXIC (Glomeruli Crystals)
- Electrolyte Disturbances (DEC Ca+ and Mg+)
- Myelosuppression
- Anemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/463/477/a_image_thumb.png?1461381800)
How many DDI does Foscarnet have?
None
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/463/478/a_image_thumb.png?1460941686)
Foscarnet Pharmacokinetics
[2-4 hour short half life] but deposits in bone
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/463/792/a_image_thumb.png?1461382040)
PriTelivir MOA
PriTelivir (Pretty boy on sketchy) =
Inhibits HSV Helicase-Primase
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/464/124/a_image_thumb.png?1460942453)
PriTelivir Indication
HSV
Replaces Foscarnet as adjunct to Acyclovir-therapies
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/464/317/a_image_thumb.png?1460942472)
Direct Acting Antivirals are used to CURE ___.
NS3 describes which HCV enzyme
Direct Acting Antivirals are used to CURE Hep C
NS3 = Protease
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/464/485/a_image_thumb.png?1460942758)
Direct Acting Antivirals are used to CURE ___.
NS5-A describes which HCV enzyme
Direct Acting Antivirals are used to CURE Hep C
NS5-A = Phosphoprotein
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/464/652/a_image_thumb.png?1460942813)
Direct Acting Antivirals are used to CURE ___.
NS5-B describes which HCV enzyme
Direct Acting Antivirals are used to CURE Hep C
NS5-B = [RNA-dependent RNA Polymerase]
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/464/683/a_image_thumb.png?1460942844)
Which inhibiting components make up the [Multidrug DAA],
Viekira? (4)
PORD
![](https://s3.amazonaws.com/brainscape-prod/system/cm/186/464/752/a_image_thumb.png?1460943123)