Anti-Viral Drugs II

Question 1

Synthetic adenosine analog with a phosphate. Technically a nucleotide RT inhibitor

Answer 1

Tenofovir

Question 2

Tenofovir’s protective groups are stripped in plasma before transport into

Answer 2

Cells

Question 3

Drug acts by competing with dATP for binding HIV RT and then chain terminates

Answer 3

Tenofovir

Question 4

Resistance to tenofovir develops slowly. The drug retains activity even with resistance to other

Answer 4

NRTIs

Question 5

Deprotected in hepatocytes (as well as lymphocytes). Therefore, it can be used at lower doses with fewer side effects than disoproxil derivative

Answer 5

Tenofovir alafenamide

Question 6

An adenosine monophosphate that is converted to a triphosphate

Answer 6

Adefovir (Hepsera)

Question 7

What are the three second-line drugs for HBV?

Answer 7

Adefovir, Lamivudine, and Telbivudine

Question 8

Effective even after the appearance of lamivudine resistance and entecavir cross resistance

Answer 8

Adefovir

Question 9

A cytosine derivative that is converted to triphosphate. Chain terminator

Answer 9

Lamivudine

Question 10

Synthetic thymidine analog active against HBV but not other viruses (HIV)

Answer 10

Telbivudine

Question 11

Lamivudine resistant strains are cross-resistant to

Answer 11

Telbivudine