Anti-HIV Drugs II

Question 1

Administered orally. Most have low systemic bioavailability

Answer 1

Protease inhibitors

Question 2

Protease inhibitors are metabolized by

Answer 2

CYP3A4

Question 3

Many drug interactions tied to interactions of PIs with

Answer 3

P450s

Question 4

Inhibits CYP3A4 and causes PIs to increase

Answer 4

Antifungal ketoconazole

Question 5

Causes CYP induction resulting in decrease of PIs

Answer 5

Rifampin

Question 6

The newest protease inhibitor, which is active against some HIV isolates that have become resistant to other PIs

Answer 6

Darunavir

Question 7

Highly bound by plasma proteins

-Inhibitor and substrate of CYP3A

Answer 7

Darunavir

Question 8

Flexibility in dosing is lost with fixed dose combination drugs. However, this is often compensated by ease of use and better

Answer 8

Compliance

Question 9

Emtricitabine/tenofovir disoproxil =

Answer 9

Truvada

Question 10

Emtricitabine/tenofovir alafenamide =

Answer 10

Descovy

Question 11

Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil =

Answer 11

Stribild

Question 12

Elvitegravir/cobicistat/emtricitabine,/ tenofovir alafenamide =

Answer 12

Genvoya

Question 13

Dolutegravir/abacavir/lamivudine =

Answer 13

Triumeq

Question 14

Bictegravir/emtricatibine/tenofovir alafenamide =

Answer 14

Biktarvy

Question 15

Now recommended for all HIV-infected individuals, regardless of their viral load or CD4 count

Answer 15

Antiretroviral Therapy (ART)

Question 16

Effective ART has recently been shown to prevent transmission of

Answer 16

HIV

Question 17

If we want to give healthcare workers post exposure prophylaxis, but the exposure was not severe, give

Answer 17

2 NRTIs for one month

Question 18

If we want to give healthcare workers post exposure prophylaxis, and the exposure was severe, give

Answer 18

ART (3 drug regimine) for one month

Question 19

For non-occupational post-exposure prophylaxis (PEP), give

Answer 19

ART for 1 month

Question 20

HIV positive women during pregnancy (who have not yet taken anti-HIV drugs) should start during the first trimester and absolutely no later than

Answer 20

28 weeks

Question 21

Which drug is recommended during delivery for an HIV positive mother?

Answer 21

IV zidovudine

Question 22

Baby should receive oral zidovudinefor

Answer 22

6 weeks after birth

Question 23

Is breast feeding recommended for HIV infected women in the US?

Answer 23

No

Question 24

Successful prophylaxis is finally a possibility because the side-effects of this dual NRTI combo pill are low and because resistance emerges slowly

Answer 24

Truvada

Question 25

When switching from one drug to another, take into consideration whether there is

Answer 25

Cross-resistance