Anti-Viral Drugs

Question 1

Describe the action of aciclovir

Answer 1

Nucleoside analogue acting on HSV and VZV

Question 2

Describe the administration of aciclovir?

Answer 2

IV, orally or topically

Question 3

What are the side effects of aciclovir?

Answer 3

Neurotoxicity as a result of renal impairment

Question 4

Give two other HSV drugs

Answer 4

Famciclovir and Valaciclobvir

Question 5

Name three anti-HIV drugs?

Answer 5

Zidovudine (AZT, ZDV), Nevirapine and Saquinavir

Question 6

How are anti-HIV drugs given?

Answer 6

In combination to improve action

Question 7

Describe the combined treatment of chronic Hep. C

Answer 7

Interferon-alpha and ribavavin

Question 8

What nucleoside analogue is used in anti-hepatitis drugs?

Answer 8

Lamivudine - oral use for Hep. B

Question 9

What two viral respiratory infection treatments are given in the first 48hrs of onset and also as post-exposure prophylaxis?

Answer 9

Zanamavir and Oseltamivir

Question 10

What nucleoside analogue is used to treat viral respiratory infections and how is it administered?

Answer 10

Ribavarin - inhalation

Question 11

Name the clinically relevant Herpes viruses

Answer 11

Varicella Zoster, Herpes Simplex, Cytomegalovirus and Epstein-Barr Virus

Question 12

What Herpes viruses are sensitive to aciclovir?

Answer 12

Herpes Simplex and Varicella-Zoster

Question 13

What drug si particularly useful against CMV?

Answer 13

Glanciclovir/valganciclovir

Question 14

Whats our anti-viral Johnny BigBalls drug for HSV, VZV and CMV?

Answer 14

Foscarnet

Question 15

What drug is used for CMV retinitis when other anti-vitals are inappropriate?

Answer 15

Cidofovir