Anti-Fungal Drugs

Question 1

What are the three mode of action for anti-fungals?

Answer 1

Ergosterol binding, ergosterol inhibition and glucan-polysaccharide synthesis inhibition

Question 2

What sub-classes of anti-fungals are there?

Answer 2

Polyenes, Azoles, Alylamines and Echinocandins

Question 3

What mode of action do polyenes have?

Answer 3

Ergosterol binding

Question 4

What mode of action do azoles have?

Answer 4

Ergosterol synthesis inhibition

Question 5

What mode of action do alylamines have?

Answer 5

Ergosterol synthesis inhibition

Question 6

What action do echinocandins have?

Answer 6

Gluten-polysaccharide synthesis inhibition

Question 7

Name two polyenes and what they treat?

Answer 7

Amphotericin-B and Nystatin

Question 8

Name two Imidazoles (older generation)

Answer 8

Miconazole and Ketoconazole

Question 9

What infections do imidazoles typically act on?

Answer 9

Dermatophytes

Question 10

Name three triazoles (newer generation)

Answer 10

Fluconazole, itraconazole and voriconazole

Question 11

What are the actions of the triazole examples?

Answer 11

• Fluconazole (yeasts) - Itrazole (everything) - Voriconazole (aspergillus)

Question 12

What example of alylamine do we have?

Answer 12

Terbinafine (dermatophyte action)

Question 13

What three echinocandin examples do we have?

Answer 13

Caspofungin, Mycafungin and Anidulafungin (all have action against aspergillus spp.)