Anti-viral drugs

Question 1

ACICLOVIR
Site of action?
Mechanism of action?
Spectrum?
Uses?
Side Effects?
Routes?
Pharmacokinetics?

Answer 1

Site of action: VIRAL NUCLEUS
Mechanism of action: INHIBITS VIRAL DNA POLYMERASE
Spectrum: SPECIFICITY FOR HERPES COMPLEX
Uses: FELINE HERPES VIRUS, VIRAL EYE INFECTION
Side Effects: MINIMAL
Routes: ORAL, IV, TOPICAL
Pharmacokinetics: WIDE DISTRIBUTION

Question 2

AMANTADINE & RIMANTADINE (OLD DRUGS)
Site of action?
Mechanism of action?
Uses?
Side Effects?
Routes?
Pharmacokinetics?

Answer 2

Site of action: VIRAL CYTOPLASM
Mechanism of action: VIRAL M2 ION CHANNEL BLOCKERS
Uses: INFLUENZA A (MAINLY IN HUMANS)
Side Effects: MINIMAL
Routes: ORAL
Pharmacokinetics: WELL ABSORBED

Question 3

ZIDOVUDINE (AZT)
Site of action?
Mechanism of action?
Spectrum?
Uses?
Side Effects?
Routes?
Pharmacokinetics?

Answer 3

Site of action: VIRAL NUCLEUS
Mechanism of action: NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR
Spectrum: SPECIFIC FOR RETROVIRUSES
Uses: HIV, FELINE LEUKEMIA VIRUS, FELINE IMMUNODEFICIENCY VIRUS
Side Effects: SHORT TERM - MINOR REVERSIBLE; LONG TERM - GIT, ANEMIA
Routes: ORAL, IV
Pharmacokinetics: CONTINUOUS ADMINISTRATION REQUIRED TO SUPRPESS VIRUS

Question 4

ZANAMIVIR (RELENZA) & OSELTAMIVIR (TAMIFLU)
Site of action?
Mechanism of action?
Spectrum?
Uses?

Answer 4

Site of action?
Mechanism of action: NEUROAMINIDASE INHIBITOR - STOPS VIRAL REPLICATION
Spectrum: INFLUENZA
Uses: INFLUENZA A AND B, CANINE PARVOVIRUS, FELINE PANLEUKOPENIA, KENNEL COUGH, CANINE FLU