Anti-viral and anti fungal drugs Y2

Question 1

Name the drug(s) and drug class used to treat HSV infections

Answer 1

Drug class: DNA polymerase inhibitors

Drug: Aciclovir & Ganciclovir

MOA: Virus replication blockage

SE: Nausea & Diarrhoea

Question 2

Name the drug (s) and drug class used to treat Influenza virus

Answer 2

Drug class: neuraminidase inhibitors

Drug name: Oseltamvir

MOA: Prevents viral budding & infectivity

SE: N&V

Question 3

What drugs and drug classes is used to treat HBV and HCV?

Answer 3

Class: Therapeutic cytokines

Name: Interferon alpha

MOA: Activates antiviral intracellular & immune response

SE: Flu like symptoms, Loss of appetite

Question 4

What drug and drug class is used to treat HCV and RSV?

Answer 4

Class: Nucleoside analogues

Name: Ribavirin

MOA: Dirupt viral RNA synthesis

SE: -

Question 5

What drugs and drug classes are used to treat HIV?

Answer 5

Nucleoside reverse transcriptase inhibitors (NRTI)

• Tenofovir
  
  • Block viral reverse transcriptase for viral replication
    
    • Rash & SJS

NON-nucleoside reverse transcriptase inhibitors (NNRTI)

• Efavirenz
  
  • Block viral reverse transcriptase for viral replication
    
    • Rash & SJS

Viral protease inhibitors

• Lopinavir
  
  • Blockade of viral protease required for virus particle assembly
    
    • GI bleed

Integrase inhibitors

• Dolutegravir
  
  • Disrupt integration of HIV genome into host chromasome
    
    • -

Viral fusion inhibitors

• Enfuvirtide
  
  • Blockade of virus fusion to target cell membrase
    
    • Pancreatitis

Chemokine receptor/ CCR5 antagonist

• Maraviroc
  
  • Blockade of HIV binding to co-factor for cell entryy
    
    • Nausea & diarrhoea

Question 6

Name all the drug classes and drugs that can be used to treat HBV

Answer 6

Therapeutic cytokines

• Interferon alpha

MOA: Activate antiviral intracellular & immune response

SE: Flu like synmptoms, Loss of appetite

Question 7

Name all the drug classes and drugs that can treat HCV

Answer 7

Nucleoside analogues

• Ribavirin
  
  • Disrupts viral RNA synthesis
    
    • Nausea & vomiting

Therapeutic cytokines

• Interferon alpha

Question 8

Name and class of drug(s) used to treat candidia infection

Answer 8

Name: Fluconazole

Drug class: Triazole anti-fungal agent

MOA: Disruption of fungal membrane function

SE: Diarrhoea & vomiting