Anti-ulcer drugs Flashcards
1
Q
How can helicobacter pylori cause peptic ulcers?
A
- Dissolves mucus enzyme (urease)
- Causes epithelial cell death: exotoxins + inflamm
- Increases acidity –> peptic ulcer
2
Q
What drugs are used to treat peptic ulcers?
A
Antibiotics
PPIs
Histamine H2 antagonists
3
Q
How do antibiotics work to treat peptic ulcers?
A
Removal of H pylori infection
4
Q
How do PPIs work to treat peptic ulcers?
A
Reduce acid production from parietal cells
5
Q
How do histamine H2 antagonists work to treat peptic ulcers?
A
Reduce acid production from parietal cells
6
Q
Why is combination therapy current best practice?
A
Address root cause AND alleviate symptoms
7
Q
How can NSAIDs cause peptic ulcers?
A
- Directly cytotoxic
- Reduces mucus production
- Increases likelihood of bleeding
- Increases acidity –> peptic ulcer
