Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PHPY 305 > Anti-Ulcer Drugs > Flashcards

Anti-Ulcer Drugs Flashcards

1
Q

Two acid related disorders

A

Ulcer

Gastro-esophageal reflux disease (GERD)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Buffering agents

A

Calcium carbonate, magnesium, aluminum hydroxide

  • add a base to acid to neutralize
  • simple to use but not strong enough for many people
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Magnesium side effects

A

Diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Calcium and aluminum side effects

A

Constipation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

H2 antagonists

A

Cimetidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cimetidine

A
  • reversible antagonists

- tolerance can develop

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Cimetidine down fall

A

Drug interactions, it is a CYP450 inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Cimetidine side effects

A
  • generally well tolerated
  • gynecomastia: increase in the male breast
  • galactorrhea: spontaneous flow of milk from the breast
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Proton Pump inhibitor

A

Omeprazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Omeprazole mechanism

A

Irreversible inhibition of the proton pump

  • binds and inhibits active proton pumps
  • potent acid suppression when used correctly
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Omeprazole side effects

A

Generally well-tolerated
Concerns over long term use
- Hypergastrinemia: increased gastrin release
- Osteoporosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Anticholinergic

A

Pirenzapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Pirenzapine mechanism

A
  • blocks muscarinic receptors
  • poor efficacy
  • many side effects
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Mucosal defence agents

A 
Prostaglandins 
- misoprostol
Coating agents
- sucralfate 
- bismuth subsalicylate (Pepto Bismol)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Misoprostol mechanism

A

Promotes secretion of mucous/bicarbonate

Inhibits acid secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Misoprostol side effects

A

Diarrhea
Abdominal cramping
Also induces abortion so contraindicated in pregnancy

17
Q

Sucralfate mechanism

A

Aluminum hydroxide + sucrose sulfate

  • forms paste
  • stimulates mucous and bicarbonate secretion
18
Q

Sucralfate side effects

A

Acts locally

Aluminum causeras constipation

19
Q

Bismuth subsalicylate mechanism

A

Forms protective barrier on ulcer
Enhances mucous and bicarbonate secretion
Inhibits growth of H Pylori and adherence to mucosa

20
Q

Main causes of Ulcers

A

H Pylori

NSAIDs

21
Q

H Pylori functions

A
  • produces inflammatory changes in mucosa
  • impairs mucosal défense
  • increases acid secretion
22
Q

Common antibiotics used for H Pylori eradication

A
  • Amoxicillin
  • Clarithromycin
  • Tetracycline
  • Metronidazole
  • Bismuth is often included in these regimens
23
Q

How to reduce GI side effects (NSAIDs)

A
  • take them with food
  • take with misoprostol
  • take with a proton pump inhibitor

PHPY 305 (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions