Anti-Thyroid Drugs Flashcards
1
Q
What is an example
A
Carbimazole
2
Q
What are the indications for use
A
Hyperthyroidism
3
Q
What is the mechanism of action
A
- Decreases uptake + conc of inorganic iodine by the thyroid
- Reduced formation of di-iodotyrosine + throxine
- Active form is methimaxole –> prevents thyroid peroxidase enzyme
- reduces T4/3
4
Q
What are the side effects
A
- headache
- Fever
- Pruritis
- Arthralgia
RARE - myopathy
- BM suppression (increase pancytopenia, agranulocytosis)
- jaundice
5
Q
What are the contra-indications
A
- Severe blood disorders
- Hepatic impairment
- Pregnancy
- breast feeding
6
Q
What are the interactions
A
Coumarins - enhances anticoagulant effect
7
Q
What to tell patient
A
tell doctor immediately of sore throat, mouth ulcer, bruising, fever, malaise, non-specific illness develops
