Anti thyroid drugs

Question 1

Classification of Thyroid treatment modalities

Answer 1

-inhibit hormone synthesis
-inhibit iodide trapping
-inhibit hormone release
-destroy thyroid tissue

Question 2

Drugs that inhibit thyroid hormone synthesis

Answer 2

-propylthiouracil
-methimazole
-carbimazole

Question 3

Drug that inhibit iodide trapping

Answer 3

-thiocyanates
-perchlorates
-pertechnetate

Question 4

Drugs that inhibit hormone release

Answer 4

-iodide, iodides of Na and K, organic iodide

Question 5

what could destroy thyroid tissue

Answer 5

radioactive iodide

Question 6

how does methimazole and carbimazole works?

Answer 6

-inhibit oxidation of iodide
-inhibit iodination of tyrosine
-inhibit coupling iodotyrosine to form T3 and T4

Question 7

side effects of propylthiouracil, carbimazole and methimazole

Answer 7

Stomach upset, nausea, vomiting, or mild rash/itching, allergic reaction, including:
rash, itching/swelling (especially of the face/tongue/throat), severe
dizziness, trouble breathing