Anti diabetic drug

Question 1

3 classes of anti-diabetic drug

Answer 1

1.insulin sensitizer
2.insulin secretagogues
3.alpha glucosidase inhibitor

Question 2

classification of anti-diabetic drug

Answer 2

1.sulfonylureas
2.meglitinides
3.biguanides
4.thiazolidinediones
5.alpha-glucosidase inhibitors.

Question 3

what is sulfonylureas, and example of drug

Answer 3

-it promotes insulin release from B-cell
-ex: tolbutamide,glyburide, glipizide,glimepiride

Question 4

what is meglitinide, and what example

Answer 4

it promotes insulin release from the beta cells, by closing the ATP-dependent K+ channel in pancreatic beta cells. this will result in the depolarization of B cells, calcium channel opening, and calcium influx.
-repaglinides
-nateglinides

Question 5

what is biguanides, and what example

Answer 5

-insulin sensitizer
-by inhibiting hepatic gluconeogenesis, decreasing intestinal absorption of carbs, decreasing hyperlipidemia, decreasing cvs mortality
-metformin

Question 6

what is thiazolidinedione and what example

Answer 6

-insulin sensitizer, by activating PPAR-gamma, then, agents that bind to PPAR-gamma will increase insulin sensitivity
-pioglitazone
-rosigglitazone

Question 7

what is alpha-glucosidase inhibitor

Answer 7

inhibit the action of alpha-glucosidase enzyme in the small intestine, resulting in a delay of digestion and absorption of carbs.

Question 8

type of insulin

Answer 8

1.rapid acting insuline (glulisine,lispro,aspart)

2.short-acting (homulin R, novolin R)

3.int-acting (Neutral Protamine Hagedorn NPH)

4.Long acting (Detemir, Glargine)