Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Cardio Pharmacology > Anti-Thrombotic Drugs > Flashcards

Anti-Thrombotic Drugs Flashcards

1
Q

What are the classes of anti-thrombotic drugs?

A
  • Anti-platelet drugs
  • Anticoagulants
  • Fibrinolytics
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are examples of anti-platelet drugs?

A
  • Aspirin
  • Clopidogrel
  • Prasugrel
  • Ticagrelor
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are examples of anticoagulants?

A

Subcutaneous :
- Heparin
- Fondaparinux

Oral :
- Warfarin
- Rivaroxaban
- Dabigatran
- Edoxaban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are examples of fibrinolytic drugs?

A
  • Streptokinase
  • Tissue plasminogen activator (tPA)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What do anti-platelet and anti-coagulant drugs prevent?

A

New thrombosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What conditions are anti-platelet drugs used in?

A
  • Angina
  • Acute myocardial infarction (MI)
  • Cerebrovascular accident (CVA)
  • Transient ischaemic attack (TIA)
  • Patients at high risk of MI and CVA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are some side effects of anti-platelet drugs?

A
  • Haemorrhage anywhere
  • Peptic ulcer leading to haemorrhage
  • Aspirin sensitivity leading to asthma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the mechanism of action of Clopidogrel, Ticagrelor and Prasugrel?

A
  • They inhibit the binding of ADP to its P2Y12 platelet receptor
  • This is thought to block the activation of the glycoprotein IIb/IIIa pathway
  • Thereby inhibiting platelet aggregation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the mechanism of action of aspirin?

A

Aspirin irreversibly inhibits cyclo-oxygenase (COX) and blocks the production of thromboxane A2 which is involved in platelet activation and aggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What conditions are anti-coagulant drugs like heparin and warfarin used in?

A
  • Deep vein thrombosis (DVT)
  • Pulmonary embolism (PE)
  • Non-ST elevated myocardial infarction (NSTEMI)
  • Atrial fibrillation (AF)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is a side effect of anti-coagulant drugs?

A

Haemorrhage anywhere

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is International Normalised Ratio (INR) ?

A

The International Normalised Ratio (INR) blood test tells you how long it takes for your blood to clot. It is used to test clotting times in people taking warfarin.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How is INR calculated?

A

By comparing the patient’s prothrombin time (PT) to a reference value - PT is a measure of how long it takes for blood to clot

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the mechanism of action of Rivaroxaban?

A

Factor Xa inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the mechanism of action of Dabigatran?

A

Thrombin factor IIa inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What does Factor Xa do?

A

Converts Prothrombin (II) to Thrombin (IIa) - key step in the formation of blood clots

17
Q

What do fibrinolytic drugs do?

A

Fibrinolytic drugs dissolve formed clots

18
Q

What conditions are fibrinolytic drugs used in?

A
  • STEMI
  • Pulmonary embolism (selected cases only)
  • Cerebrovascular accident (selected cases only)
19
Q

What is a serious side effect of fibrinolytic drugs?

A

Serious risk of haemorrhage

20
Q

In what conditions should fibrinolytic drugs be avoided?

A
  • Recent haemorrhage (some CVAs)
  • Trauma
  • Bleeding tendencies
  • Severe diabetic retinopathy
  • Peptic ulcer

Cardio Pharmacology (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions