Anti-Anginal Drugs Flashcards
What are the classes of anti-anginal drugs?
- Vasodilators
- Drugs that slow heart rate
- Metabolic modulators
What are types of anti-anginal vasodilators?
- Nitrates
- K ATP channel opener - Nicorandil
- Calcium channel blockers (dihydropyridine type)
What are types of drugs that slow the heart rate in angina treatment?
- Beta blockers
- Calcium channel blockers - Diltiazem, Verapamil
- Funny current channel modulator in the sinus node -
Ivabradine
What is an example of a metabolic modulator drug used in angina?
Ranolazine
What is the effect of nitrates on vasculature?
Nitrates are venodilators
What are examples of nitrates used for angina?
- Glyceryl trinitrate (GTN)
- Isosorbide mononitrate
What conditions are nitrates used in?
- Angina
- Acute heart failure
What are side effects of nitrates?
- Headache
- Hypotension / collapse
What is the mechanism of action of Nicorandil?
Nicorandil is a K ATP channel activator
What are side effects of Nicorandil?
- Headache
- Mouth / GI ulcers
What is the mechanism of action of Ivabradine?
Funny current channel modulator in the sinus node
Ivabradine slows the heart rate only in _____ rhythm
sinus
Does Ivabradine work in atrial fibrillation?
No
What is a side effect of Ivabradine?
Altered visual disturbance
What is the mechanism of action of Ranolazine and what condition is it used in?
- Ranolazine is a late sodium channel modulator which decreases calcium load on the heart
- Effective in refractory angina
