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YR3 Pharmacology > Anti-Seizure Drugs > Flashcards

Anti-Seizure Drugs Flashcards

1
Q

What are the major antiepileptic drugs?

A
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2
Q
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3
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4
Q
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5
Q

Outline the 3 main Mechanisms of Action of Anti-Epileptic Drugs.

A

MECHANISM OF ACTION
Antiepileptic drugs aim to inhibit the abnormal neuronal discharge rather than to correct the underlying cause.
1. Enhancement of GABA action.
2. Inhibition of sodium channel function.
3. Inhibition of calcium channel function.

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6
Q

List & Describe 3 Anti-epileptic medications which act by enhancing GABA action?

A
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7
Q

Outline how Anti-epileptic medications which Inhibit sodium channel function work.

A
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8
Q

Outline how Anti-epileptic medications which Inhibit calcium channel function work.

A
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9
Q

CARBAMAZEPINE
- Uses?
- MOA?
- Pharmacokinetic aspects?
- Unwanted effects?

A
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10
Q

PHENYTOIN
- Uses?
- MOA?
- Unwanted effects?

A

PHENYTOIN
Phenytoin is the most important member of the hydantoin group of compounds, which are structurally related to the barbiturates. It is highly effective in reducing the intensity and duration of electrically induced convulsions in mice, although ineffective against PTZ-induced convulsions. Despite its many side effects and unpredictable pharmacokinetic behaviour, phenytoin is widely used, being effective against various forms of partial and generalised seizures, although not against absence seizures, which may even get worse.

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11
Q

PHENYTOIN
- Pharmacokinetic aspects?

A
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12
Q

VALPROATE
- MOA?
- Pharmacokinetic aspects?
- Unwanted effects?

A

Unwanted effects
Valproate causes thinning and curling of the hair in about 10% of patients. The most serious side effect is hepatotoxic- ity. An increase in plasma glutamic oxaloacetic transami- nase, which signals liver damage of some degree, commonly occurs, but proven cases of valproate-induced hepatitis are rare. The few cases of fatal hepatitis in valproate-treated patients may well have been caused by other factors. Val- proate is teratogenic, causing spina bifida and other neural tube defects.

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13
Q
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14
Q

PHENOBARBITAL
- MOA?
- Pharmacokinetic aspects?

A
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15
Q

PHENOBARBITAL
- Unwanted effects?

A
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16
Q

Outline the role of BENZODIAZEPINES for the management of Epilepsy?

A
17
Q

VIGABATRIN
- MOA?
- Pharmacokinetic aspects?
- Adverse effects?

A
18
Q

LAMOTRIGINE
- MOA?
- Pharmacokinetic aspects?
- Adverse effects?

A
19
Q

FELBAMATE
- MOA?
- Pharmacokinetic aspects?
- Adverse effects?

A
20
Q

GABAPENTIN AND PREGABALIN
- MOA?
- Pharmacokinetic aspects?
- Adverse effects?

A
21
Q

TIAGABINE
- MOA?
- Pharmacokinetic aspects?
- Adverse effects?

A
22
Q

TOPIRAMATE
- MOA?
- Pharmacokinetic aspects?
- Adverse effects?

A
23
Q

LEVETIRACETAM
- MOA?
- Pharmacokinetic aspects?
- Adverse effects?

A
24
Q

Clinical uses of antiepileptic drugs?

A
25
Q
A

YR3 Pharmacology (8 decks)

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