Anti-schizophrenia 精神分裂症

Question 1

Positive sx

negative sx

Answer 1

+ve: abnormal behaviour added:
delusions, voices, thought disorder, aggressive behaviours

-ve: withdrawal from social contacts, voices saying they are not good, emo, high suicidical rates

Question 2

4 typical antipsychotics drugs

Answer 2

chlorpromazine
Haloperidol
fluphenazine
trifluoperazine

Question 3

typical and atypical antipsychotics similarity and differences

Answer 3

similarity: control +ve sx

diff: typical more epse than
atypical

Question 4

EPSE

Answer 4

actue dystonias

• pkd-like sx e.g. tremour at rest, rigidity
• reversible and only in 1st few wks

tardive dyskinesia

• irreversible
• develop slowly iver months/yrs

akathisia
- irreversible

Question 5

chlorpromazine
haloperidol
antagonism

Answer 5

D2, Anti cholinergic, H1, a1 + epse

D2, a1 + epse

Question 6

4 atypical antipsychotics

Answer 6

clozapine
olanzapine
Risperidone
Amisulpride

Question 7

clozapine
olanzapine
SE

Answer 7

anticholinergic, h1, a1, clozapine-induced agranulocytosis (monitor blood count),
DM, hyperglycemia

olanzapine: same except agranulocytosis

Question 8

Risperidone SE

Answer 8

H1, a1, DM, hyperglycemia

Question 9

Amisulpride SE

Answer 9

lack of a1, h1, anticholinergic

Cause DM, hyperglycemia (less),

women: breast swell/pain, lactation
men: gynaecomastia

Question 10

other benefit of atypical

Answer 10

WEAK -ve sx control/ ameliorate cognitive dysfunction/ stabilise mood