Anti-Psychotics

Question 1

Clozapine MOA

Answer 1

An Atypical anti-psychotic
- > has less motor side effets
- effective against the negative symptoms of schizophrenia
- effective in treatment -resistant patients
D2 receptor antagonist

Question 2

which anti-psychotics are D2 receptor antagonists

Answer 2

ALL of them

Question 3

Behavioural effects caused b D2 receptor antagonists

Answer 3

Anti-psychotic
reduce aggression
induce apathy and reduce initiative

Question 4

DA antagonism causes

Answer 4

• antipsychotic
• reduced aggression
• apathy + reduced initiative

anti-emetic
Parkinson-like symptoms
tardive dyskinesia
endocrine effects - ^ prolactin-> breast enlargement

Question 5

patient on DA antagonist for schizophrenia present with Parkinson’s like symptoms
which region of the brain has been effected?

Answer 5

Nigrostriatal regions

reversible

Question 6

Patient on DA antagonist for 2yrs for schizophrenia presents with mouth writhing, tongue protrusion

Answer 6

Tarduve dyskinesia
caused by DA antagonism
Irreversible

Question 7

What 4 other receptors are effected by the D2 antagonists used in schizophrenia?
consequences?

Answer 7

Muscarinic => atropine-like, blurred vision, urine retention, constipation , dry mouth
Histamine1 - sedative + hypnotic
alpha adrenergic -> orthostatic hypotension
5HT block -> GI disturbances