Anti-protozoal Flashcards
1
Q
What is the mechanism of action of metronidazole?
A
It serve as electron acceptor, forming cytotoxic free radicals that results in protein and DNA damage
2
Q
What is the most important anti-protozoal agent?
A
Metronidazole
3
Q
What is the antimicrobial coverage for metronidazole?
A
It has excellent anaerobic coverage
4
Q
What are the clinical indication for metronidazole?
A
Metronidazole is used to treat
- Amebic infections caused by Protozoa including Entamoeba histolytica , Trichomonas vaginalis ( vaginitis), Giardia lamblia (Giardiasis)
Although we say is an antiprotozoal agent, it is also useful in antibacterial treatment against
- Anaerobes such as Bacterioides species and Clostridium difficile (IMPT: First line treatment)
- H.pylori (part of the triple treatment, )
- surgical prophylaxis (30 to 60 min before incision)
5
Q
How is metronidazole administered and what is it CSF penetrations
A
Orally; good CSF penetration
6
Q
How is metronidazole excreted?
A
Hepatic
