Anti-Platelet Pharmacology Flashcards
1
Q
Platelet adhesion dependent on:
A
vWF binding to Gp-Ib
2
Q
Aggregation of platelets:
A
Dense granule release of ADP acting on P2Y12 Receptor -> decreases cAMP allowing platelet aggregation
3
Q
Final common pathway in platelet aggregation:
A
Gp IIb/IIIa on platelets -> allows fibrinogen cross linkage
4
Q
P2Y12 Receptor blockers:
A
- Prasugrel
- Clopidogrel
- Ticagrelor
5
Q
Gp IIb/IIIa (GP120) blockers:
A
- Eptifibatide
- Abciximab
- Tirofiban
6
Q
cAMP Modulators:
A
- Cilostazol
- Dipyridamole
7
Q
PAR Receptor Antagonists:
A
-Vorapaxar
8
Q
Clopidogrel use:
A
-Peripheral Artery Disease
9
Q
Abciximab use:
A
-Coronary stent placement to reduce death and acute MI
10
Q
Dipyridamole use:
A
-Secondary stroke prevention
11
Q
Cilostazol use:
A
-Reduces stent restenosis
12
Q
Vorapaxar use:
A
-PAD and hx of ACS
