anti-platelet agents

Question 1

What is the mechanism of action of aspirin as an antiplatelet agent?

Answer 1

Aspirin irreversibly inhibits COX-1, blocking thromboxane A2 (TXA2) production, preventing platelet aggregation.

Question 2

Name three P2Y12 inhibitors (ADP receptor blockers).

Answer 2

Clopidogrel, Prasugrel, Ticagrelor.

Question 3

What is the difference between clopidogrel and ticagrelor?

Answer 3

Clopidogrel is an irreversible P2Y12 inhibitor, while ticagrelor is reversible.

Question 4

Which class of drugs blocks the GP IIb/IIIa receptor, preventing platelet cross-linking?

Answer 4

Abciximab, Eptifibatide, Tirofiban (GP IIb/IIIa inhibitors).

Question 5

What are two phosphodiesterase inhibitors used as antiplatelets?

Answer 5

Dipyridamole, Cilostazol.

Question 6

Which antiplatelet blocks thrombin receptors (PAR-1)?

Answer 6

Vorapaxar.

Question 7

What is the most serious side effect of all antiplatelet drugs?

Answer 7

Bleeding (especially GI bleeding, hemorrhagic stroke, and thrombocytopenia).

Question 8

Which of the following drugs inhibits COX-1 irreversibly?
A) Clopidogrel
B) Ticagrelor
C) Aspirin
D) Abciximab

Answer 8

C) Aspirin

Question 9

Which P2Y12 inhibitor has the highest bleeding risk?
A) Clopidogrel
B) Prasugrel
C) Ticagrelor
D) Ticlopidine

Answer 9

B) Prasugrel

Question 10

What is the primary mechanism of GP IIb/IIIa inhibitors?
A) Blocking ADP receptors
B) Preventing thrombin activation
C) Inhibiting cAMP breakdown
D) Preventing fibrinogen cross-linking of platelets

Answer 10

D) Preventing fibrinogen cross-linking of platelets

Question 11

Which drug is used in combination with aspirin to prevent stroke and cerebrovascular disease?
A) Cilostazol
B) Dipyridamole
C) Clopidogrel
D) Abciximab

Answer 11

B) Dipyridamole

Question 12

Which drug should NOT be given to a patient with a history of stroke due to high bleeding risk?
A) Ticagrelor
B) Clopidogrel
C) Prasugrel
D) Dipyridamole

Answer 12

C) Prasugrel