adrenergic drug

Question 1

a1

Answer 1

radial muscle of iris

Question 2

b1

Answer 2

heart, kidney

Question 3

a2

Answer 3

smooth muscle, presynaptic

Question 4

b2

Answer 4

bronchial smooth muscle, uterine wall

Question 5

Epinephrin

Answer 5

• agonist on all receptor
• direct acting
• prolong anaesth.
• cardiac arrest
• anaphylactic
• shock

Question 6

NE

Answer 6

• agonist on a1, a2, b1 receptor
• hypotensive pt

Question 7

isoproterenol

Answer 7

• agonist on B1, B2
• pt w heart block

Question 8

dobutamine

Answer 8

• agonist on B1
• acute MI pt

Question 9

salbutamol, terbutaline, salmeterol, formoterol

Answer 9

• agonist B2
• bronchiole dilate
• uterine relaxant

Question 10

ritodrine, isoxsuprine

Answer 10

• agonist B2
• uterine relaxant

Question 11

Phenylephrine, methoxamine

Answer 11

• agonist a1
• nasal decongest
• mydriatic

Question 12

oxymetazoline

Answer 12

• direct agonist a1, a2
• nasal decongest

Question 13

cocaine

Answer 13

• indirect acting
• block reuptake of NE
• mechanism: block NaCl dependent NE transporter -> no transporter reuptake NE -> NE accumulate -> enhanced sympathetic actvt & longer duration of action

Question 14

ephedrine

Answer 14

-mixed acting agonist
- act on a1,a2,b1,b2 + increase NE release
- thru IV
- treat hypotension due to spinal anesthesia

Question 15

Dopamine

Answer 15

• mixed acting agonist
• receptor a1,a2,b1,d1 + increase NE
• cardiogenic shock

Question 16

mephentermine

Answer 16

• a1 + Increase NE
• hypotensive state

Question 17

adverse effect NE/EPI

Answer 17

tolong raja pergi hantar roti telur
- tachycardia
- restlessnes
- palpitation
- headache
- raise in BP
- tremors

Question 18

phenoxybenzamine

Answer 18

• irreversible, non selective, a-blockers
• a1
• reduce: vasoconstriction, peripheral resistance, BP
• increase: NE, HR
• not used as maintenance therapy for hypotension
• site of administration: orally, slow IV
  used for pheochromocytoma (benign tumor and adrenal gland)

Question 19

prazosin, terazosin, doxazosin, tamsulosin, alfuzosin

Answer 19

• selective, a1 blockers
• 1st dose may produce aggregates orthostatic hypotension (postural/syncopal)
• need to be given during bed time
• side effects: nasal stiffness, tachycardia, impaired ejaculation, impotent

Question 20

terazosin, doxazosin, alfuzosin

Answer 20

TDA
for hypertension

Question 21

propranolol, timolol

Answer 21

• 1st gene, non selective, b blockers
• avoid in pt w COPD, asthma
• long duration: reduce aqueous humor in eye

Question 22

atenolol, acebutolol, bisoprolol, esmolol, metoprolol

Answer 22

• 2nd gene, selective, B blockers
• for pt w chronic heart failure
• hypertensive pt w impaired pulmonary action

Question 23

labetalol, carvedilol

Answer 23

• 3rd gene (w vasodilatory effect), non selective B blockers
• for hypertensive emergencies
• side effect: postural hypotension, hepatotoxicity (block B1, b2, a)

Question 24

betaxolol, celiprolol, nebivolol

Answer 24

3rd gene (w vasodilatory effect), selective B blockers B1
- control hypertension + congestive cardiac failure