Anti parasitics/antimalarials Flashcards
suramin and melarsoprol is DOC for…
(Trypanosoma brucei)-AFRICAN SLEEPING SICKNESS
Benzimidazole whose inflammatory response is due to the dying parasite
Albendazole
Loiasis
Loa loa (African eye worm)
Lymphatic filariasis
Wuchereria bancrofti, Brugia malayi
DOC?
Diethylcarbamazine
Onchocerciasis (River Blindness)
onchocera volvulus
Ivermectin
DOC for
Schistosomiasis
- Schistosoma mansomi*
- Schistosoma japonicum*
- Schistosoma hematobium*
Praziquantel
Drug of Choice for:
Visceral larva migrans
(Toxocariasis)
Toxocara canis, Toxocara cati
Albendazole
anti protozoal therapy
(toxoplasmosis) DOC is
Pyrimethamine
DOC for
Fasciola hepatica (liver fluke)
Bithionol [inhibits helminth ETC]
Amebicide of choice for treating invasive amebiasis is?
METRONIDAZOLE!!!!!
[in combo with luminal agent; alternative tx is tetracycline]
•Patients should receive a luminal amebicide in addition after treatment with metronidazole
sodium stibogluconate is DOC for
all stages of leishmaniasis
gaba agonist antihelminth with the characteristic AE of Mazzotti like rxn
Ivermectin
name the Benzimidazoles
all experience increased absorptoin with a fattly meal.
all are category C and CI in pregnancy
all aim to paralyze the worm
all affect microtubules in some way
- Albendazole
- Mebendazole
- Thiabendazole (last choice)
name the mixed luminal antiamebics
“D-I-P”
- Diloxanide furoate
- Iodoquinol
- Paromomycin
TOXO encephalitis DOC
Pyrimethamine
Drug of choice for the treatment of onchocerciasis (Onchocerca volvulus), cutaneous larva migrans (ancylstoma: hookworm) & strongyloides...
ivermectin
name that drug
•Drug of choice for all forms of schistosomiasis & most trematode & cestode infections
MOA
• Increases permeability of cell membrane to calcium, causing contracture & paralysis of worm musculature, resulting in detachment of suckers from blood vessel walls.
Praziquantel
name the SYSTEMIC antiamebics:
these are useful for treating liver abscesses or intestinal wall infections
- Chloroquine [Used in combination with metronidazole (mixed) & diloxanide furoate (luminal)]
- Emetine & Dehydroemetine
Benzimidazole with the following AE: Erythema Multiforme & Steven Johnson
• Thiabendazole (last choice!)
Used as sole agent for treatment of asymptomatic amebiasis…
• Diloxanide furoate
Laxative is admin. prior to administration of _______________(oral) to purge bowel of all dead segments in order to preclude digestions & liberation of ova (may lead to cysticercosis)
niclosamide (oral)
2nd line drug for treatment of most cestode infections
name the mixed (luminal and systemic) antiamebics
- Metronidazole
- Tinidazole
DOC for Cestodes (tapeworms) generally
eg:
Taenia saginata (beef tapeworm)-Taeniasis
Taenia solium (pork tapeworm)-Taeniasis
Diphyllobothrium latum (fish tapeworm)-Diphyllobothriasis
Praziquantel or Niclosamide (need to pretreat with Laxative)
DOC
Echinococcosis
Echinococcus granulosus (dog tapeworm)
Albendazole
Name that antiamebic:
its MOA is it Interferes with bacterial protein synthesis (binds to 30S ribosomal subunits)—-which class of antimimicrobials does this drug belong to?
- Effective only against luminal forms of E.histolytica and tapeworm
- Alternative agent for cryptosporidiosis in AIDS patient
aminoglycoside!
Paromomycin
name the two antihelminth drugs that are GABA agonists
Ivermectin (do not take with other gabaergics like barbituates & benzos)
Piperazine
DOC for
Cysticercosis
Taenia solium larvae
Albendazole (#1)
or Praziquantel
Clonorchis sinensis (Oriental liver fluke)
Paragonimus westermani (lung fluke)
DOC?
Praziquantel
