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Pharmacology > Anti parasitics/antimalarials > Flashcards

Anti parasitics/antimalarials Flashcards

1
Q

suramin and melarsoprol is DOC for…

A

(Trypanosoma brucei)-AFRICAN SLEEPING SICKNESS

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2
Q

Benzimidazole whose inflammatory response is due to the dying parasite

A

Albendazole

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3
Q

Loiasis

Loa loa (African eye worm)

Lymphatic filariasis

Wuchereria bancrofti, Brugia malayi

DOC?

A

Diethylcarbamazine

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4
Q

Onchocerciasis (River Blindness)

onchocera volvulus

A

Ivermectin

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5
Q

DOC for

Schistosomiasis

  • Schistosoma mansomi*
  • Schistosoma japonicum*
  • Schistosoma hematobium*
A

Praziquantel

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6
Q

Drug of Choice for:

Visceral larva migrans

(Toxocariasis)

Toxocara canis, Toxocara cati

A

Albendazole

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7
Q

anti protozoal therapy

(toxoplasmosis) DOC is

A

Pyrimethamine

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8
Q

DOC for

Fasciola hepatica (liver fluke)

A

Bithionol [inhibits helminth ETC]

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9
Q

Amebicide of choice for treating invasive amebiasis is?

A

METRONIDAZOLE!!!!!

[in combo with luminal agent; alternative tx is tetracycline]

•Patients should receive a luminal amebicide in addition after treatment with metronidazole

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10
Q

sodium stibogluconate is DOC for

A

all stages of leishmaniasis

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11
Q

gaba agonist antihelminth with the characteristic AE of Mazzotti like rxn

A

Ivermectin

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12
Q

name the Benzimidazoles

all experience increased absorptoin with a fattly meal.

all are category C and CI in pregnancy

all aim to paralyze the worm

all affect microtubules in some way

A
  • Albendazole
  • Mebendazole
  • Thiabendazole (last choice)
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13
Q
A
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14
Q

name the mixed luminal antiamebics

“D-I-P”

A
  • Diloxanide furoate
  • Iodoquinol
  • Paromomycin
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15
Q

TOXO encephalitis DOC

A

Pyrimethamine

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16
Q

Drug of choice for the treatment of onchocerciasis (Onchocerca volvulus), cutaneous larva migrans (ancylstoma: hookworm) & strongyloides...

A

ivermectin

17
Q

name that drug

•Drug of choice for all forms of schistosomiasis & most trematode & cestode infections

MOA

• Increases permeability of cell membrane to calcium, causing contracture & paralysis of worm musculature, resulting in detachment of suckers from blood vessel walls.

A

Praziquantel

18
Q

name the SYSTEMIC antiamebics:

these are useful for treating liver abscesses or intestinal wall infections

A
  • Chloroquine [Used in combination with metronidazole (mixed) & diloxanide furoate (luminal)]
  • Emetine & Dehydroemetine
19
Q

Benzimidazole with the following AE: Erythema Multiforme & Steven Johnson

A

• Thiabendazole (last choice!)

20
Q

Used as sole agent for treatment of asymptomatic amebiasis…

A

• Diloxanide furoate

21
Q

Laxative is admin. prior to administration of _______________(oral) to purge bowel of all dead segments in order to preclude digestions & liberation of ova (may lead to cysticercosis)

A

niclosamide (oral)

2nd line drug for treatment of most cestode infections

22
Q

name the mixed (luminal and systemic) antiamebics

A
  • Metronidazole
  • Tinidazole
23
Q

DOC for Cestodes (tapeworms) generally

eg:

Taenia saginata (beef tapeworm)-Taeniasis

Taenia solium (pork tapeworm)-Taeniasis

Diphyllobothrium latum (fish tapeworm)-Diphyllobothriasis

A

Praziquantel or Niclosamide (need to pretreat with Laxative)

24
Q

DOC

Echinococcosis

Echinococcus granulosus (dog tapeworm)

A

Albendazole

25
Q

Name that antiamebic:

its MOA is it Interferes with bacterial protein synthesis (binds to 30S ribosomal subunits)—-which class of antimimicrobials does this drug belong to?

  • Effective only against luminal forms of E.histolytica and tapeworm
  • Alternative agent for cryptosporidiosis in AIDS patient
A

aminoglycoside!

Paromomycin

26
Q

name the two antihelminth drugs that are GABA agonists

A

Ivermectin (do not take with other gabaergics like barbituates & benzos)

Piperazine

27
Q

DOC for

Cysticercosis

Taenia solium larvae

A

Albendazole (#1)

or Praziquantel

28
Q

Clonorchis sinensis (Oriental liver fluke)

Paragonimus westermani (lung fluke)

DOC?

A

Praziquantel

Pharmacology (14 decks)

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