Anti-Neoplastic Drugs

Question 1

Cyclophosphamide toxicities

Answer 1

Cardiotoxicity
Hemorrhagic cystitis
“Bladder Burn” or hematuria

Question 2

Methotrexate mechanism

Answer 2

Analog of folic acid

Competitively inhibits dihydrofolate reductase (blocks dTMP synthesis required for DNA synthesis)

Question 3

Leucovorin function

Answer 3

Folinic acid that does not require dihydrofolate reductase

Decreases effect of methotrexate

Question 4

5-flurouracil mechanism

Answer 4

Blocks thymidylate synthatase
Can incorporate into RNA and interfere w/ processing
Can incorporate into DNA and inhibit synthesis

Question 5

5-FU toxicities

Answer 5

Severe ulceration of oral and GI mucosa

Diarrhea

Question 6

Mercaptopurine mechanism

Answer 6

Causes DNA breaks

Question 7

What is critical for 6-Mercaptopurine activation?

Answer 7

HGPRT

Question 8

What is Mercaptopurine used to treat?

Answer 8

Leukemia in children

Question 9

Imatinib mechanism

Answer 9

Inhibits constitutively active Bcr-Abl tyrosine kinase

Competes with ATP for binding to the kinase domain of Bcr-Abl

Question 10

Imatinib administration

Answer 10

Continuous