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HEME II > Anti-Neoplastic Agents > Flashcards

Anti-Neoplastic Agents Flashcards

1
Q

Cyclophosphamide

A

Nitrogen Mustards

Alkylating Agents

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2
Q

Ifosfamide

A

Nitrogen Mustards

Alkylating Agents

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3
Q

Busulfan

A

Alkyl Sulfonate

Alkylating Agents

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4
Q

Cisplatin

A

Platinum Coordination Complexes

Alkylating Agents

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5
Q

Methotrexate

A

Folic Acid analog

Anti-metabolites

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6
Q

Fluorouracil

A

Pyrimidine Analog

Anti-metabolites

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7
Q

Mercaptopurine

A

Purine Analog

Anti-metabolites

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8
Q

Vinblastine

A

Vinca alkaloids

Natural Products

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9
Q

Vincristine

A

Vinca alkaloids

Natural Products

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10
Q

Paclitaxel

A

Taxanes

Natural Products

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11
Q

Etoposide

A

Epipodophyllotoxins

Natural Products

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12
Q

Doxorubicin

A

Antibiotics

Natural Products

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13
Q

Bleomycin

A

Anthracenedione

Natural Products

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14
Q

L-Asparaginase

A

Enzymes

Natural Products

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15
Q

Imatinib

A

Protein Tyrosine Kinase Inhibitors

Miscellaneous Agents

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16
Q

Leucovorin

A

Rescue agents

17
Q

Mesna

A

Rescue agents

18
Q

Filgrastim

A

Agent used to minimize adverse effects

19
Q

Erythropoietin

A

Agent used to minimize adverse effects

20
Q

Ondansetron

A

Serotonin antagonists

Agents used to minimize adverse effects

21
Q

Procarbazine

A

Methylhydrazine derivative

Alkylating Agents

22
Q

Carmustine

A

Nitrosoureas

Alkylating Agents

23
Q

Dacarbazine

A

Triazenes

Alkylating Agents

24
Q

Mesna

A

Inactivates acrolein

Used as prophylaxis for chemotherapy related hemorrhagic cystitis

25
Q

Trastuzumab

A

HER2/neu Monoclonal Ab

26
Q

What’s the order of the cell cycle?

A

G0 –> G1 –> S –> G2 –> M

27
Q

What happens in each phase of the cell cycle

A

G0 Rest
G1: Synthesis of cellular components needed for DNA synthesis
S: DNA Synthesis
G2: Synthesis of cellular components for mitosis
M: Mitosis

28
Q

Growth fraction

A

Proliferating Cells/ Cells in G0

29
Q

Antineoplastic drugs work best on cancers with what type of growth fraction?

A

HIGH!!

30
Q

Log Cell Kill Hypothesis

A

Chemotherapy kills a fraction of cells rather than an absolute number per dose

31
Q

Intermittent high dose therapy is associated with CCS/CCNS?

A

CCNS

32
Q

Continous infusion therapy is associated with CCS/CNNS?

A

CCS

33
Q

Treatment induced tumors occur most commonly after Tx with what?

A

Alkylating agents

34
Q

What inhibits osteoclast action and bone resorption and may be used to delay the time to the first skeletal complication

A

Biphosphonates

35
Q

Cardiotoxicity with Dysrhythmias and Heart Failure

A

Doxorubicin

36
Q

Pulmonary toxicity

A

Bleomycin

HEME II (2 decks)

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