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HEME II > Anti-Neoplastic Agents > Flashcards

Anti-Neoplastic Agents Flashcards

1
Q

Cyclophosphamide

A

Nitrogen Mustards

Alkylating Agents

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2
Q

Ifosfamide

A

Nitrogen Mustards

Alkylating Agents

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3
Q

Busulfan

A

Alkyl Sulfonate

Alkylating Agents

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4
Q

Cisplatin

A

Platinum Coordination Complexes

Alkylating Agents

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5
Q

Methotrexate

A

Folic Acid analog

Anti-metabolites

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6
Q

Fluorouracil

A

Pyrimidine Analog

Anti-metabolites

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7
Q

Mercaptopurine

A

Purine Analog

Anti-metabolites

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8
Q

Vinblastine

A

Vinca alkaloids

Natural Products

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9
Q

Vincristine

A

Vinca alkaloids

Natural Products

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10
Q

Paclitaxel

A

Taxanes

Natural Products

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11
Q

Etoposide

A

Epipodophyllotoxins

Natural Products

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12
Q

Doxorubicin

A

Antibiotics

Natural Products

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13
Q

Bleomycin

A

Anthracenedione

Natural Products

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14
Q

L-Asparaginase

A

Enzymes

Natural Products

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15
Q

Imatinib

A

Protein Tyrosine Kinase Inhibitors

Miscellaneous Agents

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16
Q

Leucovorin

A

Rescue agents

17
Q

Mesna

A

Rescue agents

18
Q

Filgrastim

A

Agent used to minimize adverse effects

19
Q

Erythropoietin

A

Agent used to minimize adverse effects

20
Q

Ondansetron

A

Serotonin antagonists

Agents used to minimize adverse effects

21
Q

Procarbazine

A

Methylhydrazine derivative

Alkylating Agents

22
Q

Carmustine

A

Nitrosoureas

Alkylating Agents

23
Q

Dacarbazine

A

Triazenes

Alkylating Agents

24
Q

Mesna

A

Inactivates acrolein

Used as prophylaxis for chemotherapy related hemorrhagic cystitis

25
Trastuzumab
HER2/neu Monoclonal Ab
26
What's the order of the cell cycle?
G0 --> G1 --> S --> G2 --> M
27
What happens in each phase of the cell cycle
G0 Rest G1: Synthesis of cellular components needed for DNA synthesis S: DNA Synthesis G2: Synthesis of cellular components for mitosis M: Mitosis
28
Growth fraction
Proliferating Cells/ Cells in G0
29
Antineoplastic drugs work best on cancers with what type of growth fraction?
HIGH!!
30
Log Cell Kill Hypothesis
Chemotherapy kills a fraction of cells rather than an absolute number per dose
31
Intermittent high dose therapy is associated with CCS/CCNS?
CCNS
32
Continous infusion therapy is associated with CCS/CNNS?
CCS
33
Treatment induced tumors occur most commonly after Tx with what?
Alkylating agents
34
What inhibits osteoclast action and bone resorption and may be used to delay the time to the first skeletal complication
Biphosphonates
35
Cardiotoxicity with Dysrhythmias and Heart Failure
Doxorubicin
36
Pulmonary toxicity
Bleomycin

HEME II (2 decks)

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