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HemeOnc Block 2 > anti-neo ibook questions > Flashcards

anti-neo ibook questions Flashcards

1
Q

MOA: produce metal chelating complex to induce free radicals to damage phosphodiester bond of DNA

A

bleomycin

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2
Q

MOA: DNA damaged by quinone induced free radicals, ROS and H2O2

A

rubicins

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3
Q

MOA: intercalate DNA

A

rubicins

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4
Q

MOA: block topoisomerase II

A

rubicins, etoposide, teniposide

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5
Q

AE: cardiotoxicity, extravasation, and dose-limiting myelosuppression

A

rubicins

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6
Q

AE: pulmonary fibrosis and hyperpigmentation

A

Bleomycin

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7
Q

AE: infusion reactions, hypotension, hypersensitivity

A

paclitaxel and etoposide

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8
Q

AE: dose-limiting myelosuppression

A

topotecan, vinblastine, pacitaxel

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9
Q

AE: severe myelosuppression

A

teniposide, topotecan, vinblastine, pacitaxel

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10
Q

AE: diarrhea

A

irinotecan, 5-FU

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11
Q

AE: peripheral neuropathy

A

paclitaxel and vincristine

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12
Q

MOA: block topoisomerase II

A

etoposide and teniposide

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13
Q

MOA: block topoisomerase I

A

topotecan and irinotecan

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14
Q

MOA: inhibits microtubule polymerization

A

vincristine and vinblastine

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15
Q

MOA: inhibits dissociation of microtubules

A

paclitaxel and docetaxel, other taxanes

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16
Q

MOA: thymidine inhibitor

A

capecitibine and 5-FU

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17
Q

MOA: cytidine inhibitor

A

cytarabine

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18
Q

MOA: purine inhibitor

A

6-MP

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19
Q

MOA: folate inhibitor

A

MTX

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20
Q

AE: hand and foot syndrome

A

5-FU and capecitibine

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21
Q

AE: crystalluria

A

MTX

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22
Q

AE: severe myelosuppression

A

MTX and 5-FU

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23
Q

HGPRT enzyme to make fraudulent nucleotides

A

6-MP

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24
Q

DHFR enzyme

A

MTX

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25
Q

Thymidylate phosphorylase

A

capecitibine

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26
Q

Thymidylate synthetase

A

5-FU

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27
Q

DNA polymerase

A

Ara C (cytarabine)

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28
Q

Rituximab target

A

CD20

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29
Q

Natalizumab target

A

alpha 4 integrin

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30
Q

Trastuzumab and pertuzumab target

A

HER-2

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31
Q

Alemtuzimab target

A

CD52

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32
Q

AE of Alemtuzimab

A

severe long term myelosuppression

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33
Q

AE of rituximab and trastuzumab

A

infusion reaction

34
Q

AE of natalizumab

A

opportunistic infections

35
Q

AE of trastuzumab- ematansine

A

well tolerated drug

36
Q

AE of pertuzumab

A

alopecia, fatigue, pain, diarrhea

37
Q

AE: extravasation

A

mechlorethamine

38
Q

AE: disulfram like reaction

A

procarbazine

39
Q

AE: hemorrhagic cystitis

A

cyclophosphamide and ifosfamide

40
Q

AE: ototoxicity

A

cisplatin

41
Q

AE: pulmonary fibrosis

A

busulfan and bleomycin

42
Q

AE: emetogenesis (most severe)

A

cisplatin and cyclophosphamide

43
Q

AE: teratogen/carcinogen/mutagen

A

chlorambucil

44
Q

drug selectively binds to the cells actively transport phenyl alanine

A

melphalan

45
Q

drug to treat brain tumores

A

dacarbazine and carmustine

46
Q

drug used for wafer implant delivery

A

carmustine

47
Q

typical alkylating agent with a half life of about one minute (shortest half life, super unstable)

A

mechlorethamine

48
Q

targets estrogen receptor

A

tamoxifen

49
Q

blocks androgen receptor

A

flutamide

50
Q

inhibits estrogen synthesis

A

anastrazole

51
Q

combination drug for lymphoma

A

prednisone

52
Q

ER+ breast cancer in post-menopausal woman

A

anastrazole

53
Q

ER+ breast cancer in pre-menopausal woman

A

tamoxifen

54
Q

prostate cancer

A

flutamide

55
Q

red devil

A

rubicins

56
Q

nitrogen mustard

A

mechlorethamine

57
Q

thymine-less death

A

fluoro uracil

58
Q

vinca alkaloid

A

vincristine

59
Q

platinum analog

A

oxaliplatin

60
Q

thio-guanine

A

mercaptopurine

61
Q

crosslinking DNA

A

cyclophosphamide

62
Q

intercalating DNA

A

rubicins

63
Q

metal-chelating DNA

A

bleomycin

64
Q

inhibit DNA polymerase enzyme

A

cytarabine

65
Q

inhibit DNA topoisomerase I

A

topotecan

66
Q

DNA fraudulent nucleotide

A

mercaptopurine

67
Q

agent to avoid anti-neoplastic drug induced bloody urine

A

mercaptoethane sulfonate sodium (mesna)

68
Q

agent to use in 5-FU overdose

A

uridine triacetate

69
Q

agent to enhance 5-FU activity

A

leucovorine

70
Q

agent to tx MTX overdose

A

leucovorine

71
Q

agent used as an antidote for mechlorethamine extravasation

A

sodium thiosulfate

72
Q

agent to administer with MTX to rescue normal cells

A

leucovorine

73
Q

taxanes

A

paclitaxel and docetaxel

74
Q

camptothecin

A

topotican

75
Q

anthracycline

A

rubicins

76
Q

SN-38

A

irinotecan

77
Q

acrolein

A

ifosfamide and cyclophosphamide

78
Q

DPD enzyme test

A

5-FU

79
Q

UGT1A1 test

A

irinotecan

80
Q

TPMT test

A

6-MP

81
Q

prodrug of dacarbazine

A

temozolmide

HemeOnc Block 2 (3 decks)

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