anti-neo ibook questions

Question 1

MOA: produce metal chelating complex to induce free radicals to damage phosphodiester bond of DNA

Answer 1

bleomycin

Question 2

MOA: DNA damaged by quinone induced free radicals, ROS and H2O2

Answer 2

rubicins

Question 3

MOA: intercalate DNA

Answer 3

rubicins

Question 4

MOA: block topoisomerase II

Answer 4

rubicins, etoposide, teniposide

Question 5

AE: cardiotoxicity, extravasation, and dose-limiting myelosuppression

Answer 5

rubicins

Question 6

AE: pulmonary fibrosis and hyperpigmentation

Answer 6

Bleomycin

Question 7

AE: infusion reactions, hypotension, hypersensitivity

Answer 7

paclitaxel and etoposide

Question 8

AE: dose-limiting myelosuppression

Answer 8

topotecan, vinblastine, pacitaxel

Question 9

AE: severe myelosuppression

Answer 9

teniposide, topotecan, vinblastine, pacitaxel

Question 10

AE: diarrhea

Answer 10

irinotecan, 5-FU

Question 11

AE: peripheral neuropathy

Answer 11

paclitaxel and vincristine

Question 12

MOA: block topoisomerase II

Answer 12

etoposide and teniposide

Question 13

MOA: block topoisomerase I

Answer 13

topotecan and irinotecan

Question 14

MOA: inhibits microtubule polymerization

Answer 14

vincristine and vinblastine

Question 15

MOA: inhibits dissociation of microtubules

Answer 15

paclitaxel and docetaxel, other taxanes

Question 16

MOA: thymidine inhibitor

Answer 16

capecitibine and 5-FU

Question 17

MOA: cytidine inhibitor

Answer 17

cytarabine

Question 18

MOA: purine inhibitor

Answer 18

6-MP

Question 19

MOA: folate inhibitor

Answer 19

MTX

Question 20

AE: hand and foot syndrome

Answer 20

5-FU and capecitibine

Question 21

AE: crystalluria

Answer 21

MTX

Question 22

AE: severe myelosuppression

Answer 22

MTX and 5-FU

Question 23

HGPRT enzyme to make fraudulent nucleotides

Answer 23

6-MP

Question 24

DHFR enzyme

Answer 24

MTX

Question 25

Thymidylate phosphorylase

Answer 25

capecitibine

Question 26

Thymidylate synthetase

Answer 26

5-FU

Question 27

DNA polymerase

Answer 27

Ara C (cytarabine)

Question 28

Rituximab target

Answer 28

CD20

Question 29

Natalizumab target

Answer 29

alpha 4 integrin

Question 30

Trastuzumab and pertuzumab target

Answer 30

HER-2

Question 31

Alemtuzimab target

Answer 31

CD52

Question 32

AE of Alemtuzimab

Answer 32

severe long term myelosuppression

Question 33

AE of rituximab and trastuzumab

Answer 33

infusion reaction

Question 34

AE of natalizumab

Answer 34

opportunistic infections

Question 35

AE of trastuzumab- ematansine

Answer 35

well tolerated drug

Question 36

AE of pertuzumab

Answer 36

alopecia, fatigue, pain, diarrhea

Question 37

AE: extravasation

Answer 37

mechlorethamine

Question 38

AE: disulfram like reaction

Answer 38

procarbazine

Question 39

AE: hemorrhagic cystitis

Answer 39

cyclophosphamide and ifosfamide

Question 40

AE: ototoxicity

Answer 40

cisplatin

Question 41

AE: pulmonary fibrosis

Answer 41

busulfan and bleomycin

Question 42

AE: emetogenesis (most severe)

Answer 42

cisplatin and cyclophosphamide

Question 43

AE: teratogen/carcinogen/mutagen

Answer 43

chlorambucil

Question 44

drug selectively binds to the cells actively transport phenyl alanine

Answer 44

melphalan

Question 45

drug to treat brain tumores

Answer 45

dacarbazine and carmustine

Question 46

drug used for wafer implant delivery

Answer 46

carmustine

Question 47

typical alkylating agent with a half life of about one minute (shortest half life, super unstable)

Answer 47

mechlorethamine

Question 48

targets estrogen receptor

Answer 48

tamoxifen

Question 49

blocks androgen receptor

Answer 49

flutamide

Question 50

inhibits estrogen synthesis

Answer 50

anastrazole

Question 51

combination drug for lymphoma

Answer 51

prednisone

Question 52

ER+ breast cancer in post-menopausal woman

Answer 52

anastrazole

Question 53

ER+ breast cancer in pre-menopausal woman

Answer 53

tamoxifen

Question 54

prostate cancer

Answer 54

flutamide

Question 55

red devil

Answer 55

rubicins

Question 56

nitrogen mustard

Answer 56

mechlorethamine

Question 57

thymine-less death

Answer 57

fluoro uracil

Question 58

vinca alkaloid

Answer 58

vincristine

Question 59

platinum analog

Answer 59

oxaliplatin

Question 60

thio-guanine

Answer 60

mercaptopurine

Question 61

crosslinking DNA

Answer 61

cyclophosphamide

Question 62

intercalating DNA

Answer 62

rubicins

Question 63

metal-chelating DNA

Answer 63

bleomycin

Question 64

inhibit DNA polymerase enzyme

Answer 64

cytarabine

Question 65

inhibit DNA topoisomerase I

Answer 65

topotecan

Question 66

DNA fraudulent nucleotide

Answer 66

mercaptopurine

Question 67

agent to avoid anti-neoplastic drug induced bloody urine

Answer 67

mercaptoethane sulfonate sodium (mesna)

Question 68

agent to use in 5-FU overdose

Answer 68

uridine triacetate

Question 69

agent to enhance 5-FU activity

Answer 69

leucovorine

Question 70

agent to tx MTX overdose

Answer 70

leucovorine

Question 71

agent used as an antidote for mechlorethamine extravasation

Answer 71

sodium thiosulfate

Question 72

agent to administer with MTX to rescue normal cells

Answer 72

leucovorine

Question 73

taxanes

Answer 73

paclitaxel and docetaxel

Question 74

camptothecin

Answer 74

topotican

Question 75

anthracycline

Answer 75

rubicins

Question 76

SN-38

Answer 76

irinotecan

Question 77

acrolein

Answer 77

ifosfamide and cyclophosphamide

Question 78

DPD enzyme test

Answer 78

5-FU

Question 79

UGT1A1 test

Answer 79

irinotecan

Question 80

TPMT test

Answer 80

6-MP

Question 81

prodrug of dacarbazine

Answer 81

temozolmide