Anti-Malarials Flashcards
Chloroquine
Blood Schizonticide
Mefloquine
Blood Schizonticide
Quinine
Blood Schizonticide
Primaquine
Liver schizonts (vivax+ovale)
Antifolates pyrimethamine, proguanil, sulfadoxine
Blood schizonticide (falciparum)
Atovaquone-Proguanil
Blood schizonticide (falciparum)
Artesunate, artemether
Blood schizonticide (falciparum), including multidrug resistant strain
Proguanil
Slow acting blood schizonticide + prevents sporogeny in mosquito
Pyrimethamine
Blood schizonticide
Chloroquine MOA?
Intracellular heme accumulation
Mefloquine MOA?
unknown
Quinine MOA?
DNA complexer; prevents strand separation
Primaquine MOA?
Free radical generator
Antifolates pyrimethamine, proguanil, sulfadoxine MOA?
P’s are DHFR inhibitors, sulfadoxine is dihydropteroate synthase inhibitor
Atovaquone-Proguanil MOA?
Inhibits mitochondrial ETC