Anti-Malarials Flashcards

1
Q

Chloroquine

A

Blood Schizonticide

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2
Q

Mefloquine

A

Blood Schizonticide

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3
Q

Quinine

A

Blood Schizonticide

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4
Q

Primaquine

A

Liver schizonts (vivax+ovale)

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5
Q

Antifolates pyrimethamine, proguanil, sulfadoxine

A

Blood schizonticide (falciparum)

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6
Q

Atovaquone-Proguanil

A

Blood schizonticide (falciparum)

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7
Q

Artesunate, artemether

A

Blood schizonticide (falciparum), including multidrug resistant strain

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8
Q

Proguanil

A

Slow acting blood schizonticide + prevents sporogeny in mosquito

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9
Q

Pyrimethamine

A

Blood schizonticide

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10
Q

Chloroquine MOA?

A

Intracellular heme accumulation

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11
Q

Mefloquine MOA?

A

unknown

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12
Q

Quinine MOA?

A

DNA complexer; prevents strand separation

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13
Q

Primaquine MOA?

A

Free radical generator

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14
Q

Antifolates pyrimethamine, proguanil, sulfadoxine MOA?

A

P’s are DHFR inhibitors, sulfadoxine is dihydropteroate synthase inhibitor

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15
Q

Atovaquone-Proguanil MOA?

A

Inhibits mitochondrial ETC

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16
Q

Artesunate, artemether MOA?

A

Free radical generator

17
Q

Mebendazole MOA?

A

Microtubule inhibitor

18
Q

Praziquantel MOA?

A

Inc Ca2+ entry leading to paralysis

19
Q

Pentamidine MOA?

A

Unknown

20
Q

Atovaquone MOA?

A

Inhibits ETC