Anti-Leprosy Drugs

Question 1

AKA “Hansen’s Disease

Answer 1

Leprosy

Question 2

Leprosy is caused by?

Answer 2

Chronic infectious disease caused by Mycobacterium leprae

Question 3

Characterized by intact cell-mediated immunity, a positive lepromin skin
reaction, granuloma formation, and a relative paucity of bacilli.

Answer 3

TUBERCULOID LEPROSY

Question 4

Characterized by depressed cell-mediated immunity, numerous bacilli within
the tissues, no granulomas, and negative skin test for lepromin.

Answer 4

LEPROMATOUS LEPROSY

Question 5

What are drugs for Leprosy?

Answer 5

1. Sulfones
2. Clofazimine
3. Ethionamide & Prothionamide

Question 6

DOC for leprosy

Answer 6

DAPSONE (Avlosulfon ®)

Question 7

Treatment and prevention of Pneumocystis carinii pneumonia (PCP) in AIDS
patients who are allergic to or intolerant to trimethoprim-sulfamethoxazole.

Answer 7

DAPSONE (Avlosulfon ®)

Question 8

A/E of Dapsone?

Answer 8

A/E: Erythema Nodosum Leprosum

Question 9

Diacetylsulfone, for who cannot tolerate long-term oral
dapsone therapy.

Answer 9

Acedapsone

Question 10

Phenazine Dye?

Answer 10

Clofazimine

Question 11

Treat sulfone-resistant leprosy or to patients who are intolerant to sulfones.

Answer 11

Clofazimine

Question 12

A/E of Clofazimine?

Answer 12

Red-brown discoloration of the skin esp. in light skinned
persons.

Question 13

Alternatives to Clofazimine in the treatment of MDR leprosy

Answer 13

ETHIONAMIDE & PROTHIONAMIDE